A0A4Q1SJP9 · A0A4Q1SJP9_9BACT
- ProteinAdenosine 5'-phosphosulfate reductase
- GenecysH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids244 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
Catalytic activity
- [thioredoxin]-disulfide + sulfite + AMP + 2 H+ = adenosine 5'-phosphosulfate + [thioredoxin]-dithiol
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:17359 + CHEBI:456215 + 2 CHEBI:15378 = CHEBI:58243 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 114 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 115 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 200 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 203 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Active site | 225 | Nucleophile; cysteine thiosulfonate intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | adenylyl-sulfate reductase (thioredoxin) activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoadenylyl-sulfate reductase (thioredoxin) activity | |
Biological Process | sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine 5'-phosphosulfate reductase
- EC number
- Short namesAPS reductase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Acidobacteriota > Terriglobia > Terriglobales > Acidobacteriaceae > Silvibacterium
Accessions
- Primary accessionA0A4Q1SJP9
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 34-205 | Phosphoadenosine phosphosulphate reductase | |||
Sequence similarities
Belongs to the PAPS reductase family. CysH subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length244
- Mass (Da)27,089
- Last updated2019-07-31 v1
- Checksum0910F7EBA028D297
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
SDMK01000001 EMBL· GenBank· DDBJ | RXS97888.1 EMBL· GenBank· DDBJ | Genomic DNA |