A0A4P8PFK8 · A0A4P8PFK8_9FABA

  • Protein
    NADH-ubiquinone oxidoreductase chain 4
  • Gene
    nad4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentplastid
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Molecular Functionubiquinone binding
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Gene names

    • Name
      nad4

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > genistoids sensu lato > core genistoids > Sophoreae > Ammopiptanthus

Accessions

  • Primary accession
    A0A4P8PFK8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-29Helical
Transmembrane36-54Helical
Transmembrane89-107Helical
Transmembrane143-161Helical
Transmembrane173-194Helical
Transmembrane214-237Helical
Transmembrane307-326Helical
Transmembrane338-356Helical
Transmembrane413-433Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain140-419NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    495
  • Mass (Da)
    54,951
  • Last updated
    2019-07-31 v1
  • Checksum
    133E6DBF5714E761
MLEHFCECYSDLSGPILCPVLGSIIPLFIPNSRIRPIRLIGLCASLITFLYSPVPRIQFDPSTAKSQFVESLRWLPYENINFNLGIDGLSFFFVILTTFLIPICILVGWSGMRSYGKEYITASLIREFLMIAVFRMLDPLLFYVLPESVLIPMFIIIGVWGSRQRKIKAAYQFFLYTLLGSVFMLLAILLILFQTGTADLQISLTTEFSERRQIFLWIASFAAFAVKVPMVPVHIWLPEAHVEAPTAGSVILAGIPSKLGTHGFLRFSIPMFPEATLCSTPFIYTPSAIAIIYTSLTTSRQIDLKKIIAYSSVAHMNLVTIGMFSPNIQGIGGSIPPMLSHGLVPSALFLCVGVLYDRHKTRLVRYYGGLVSTMPNLSTISFSSTLANMSSPGTSSFIGEFPISVGAFQRNSLVATLAALGMILGAAYSLWLYNRVVSGNLKPDFLHKFSDPNGREVSIFIPFLVGVVRMGVHPKVFPDRMHTYVSNLVQHGKFH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG011535
EMBL· GenBank· DDBJ
QCQ81906.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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