A0A4P8PFK8 · A0A4P8PFK8_9FABA
- ProteinNADH-ubiquinone oxidoreductase chain 4
- Genenad4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial membrane | |
Cellular Component | plastid | |
Cellular Component | respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Molecular Function | ubiquinone binding | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | electron transport coupled proton transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 4
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > genistoids sensu lato > core genistoids > Sophoreae > Ammopiptanthus
Accessions
- Primary accessionA0A4P8PFK8
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-29 | Helical | ||||
Sequence: LSGPILCPVLGSIIPLFI | ||||||
Transmembrane | 36-54 | Helical | ||||
Sequence: PIRLIGLCASLITFLYSPV | ||||||
Transmembrane | 89-107 | Helical | ||||
Sequence: LSFFFVILTTFLIPICILV | ||||||
Transmembrane | 143-161 | Helical | ||||
Sequence: YVLPESVLIPMFIIIGVWG | ||||||
Transmembrane | 173-194 | Helical | ||||
Sequence: FFLYTLLGSVFMLLAILLILFQ | ||||||
Transmembrane | 214-237 | Helical | ||||
Sequence: IFLWIASFAAFAVKVPMVPVHIWL | ||||||
Transmembrane | 307-326 | Helical | ||||
Sequence: IIAYSSVAHMNLVTIGMFSP | ||||||
Transmembrane | 338-356 | Helical | ||||
Sequence: MLSHGLVPSALFLCVGVLY | ||||||
Transmembrane | 413-433 | Helical | ||||
Sequence: LVATLAALGMILGAAYSLWLY |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 140-419 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: LLFYVLPESVLIPMFIIIGVWGSRQRKIKAAYQFFLYTLLGSVFMLLAILLILFQTGTADLQISLTTEFSERRQIFLWIASFAAFAVKVPMVPVHIWLPEAHVEAPTAGSVILAGIPSKLGTHGFLRFSIPMFPEATLCSTPFIYTPSAIAIIYTSLTTSRQIDLKKIIAYSSVAHMNLVTIGMFSPNIQGIGGSIPPMLSHGLVPSALFLCVGVLYDRHKTRLVRYYGGLVSTMPNLSTISFSSTLANMSSPGTSSFIGEFPISVGAFQRNSLVATLAA |
Sequence similarities
Belongs to the complex I subunit 4 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)54,951
- Last updated2019-07-31 v1
- Checksum133E6DBF5714E761