A0A4P8EGY5 · A0A4P8EGY5_9RHOB
- Proteincytochrome-c oxidase
- GeneccoN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids533 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 copper ion per subunit, denoted as copper B.
Note: Binds 2 heme groups per subunit, denoted as high- and low-spin.
Pathway
Energy metabolism; oxidative phosphorylation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 116 | Fe (UniProtKB | ChEBI) of heme b 1; low-spin (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 265 | Cu cation B (UniProtKB | ChEBI) | |||
Binding site | 315 | Cu cation B (UniProtKB | ChEBI) | |||
Binding site | 316 | Cu cation B (UniProtKB | ChEBI) | |||
Binding site | 403 | Fe (UniProtKB | ChEBI) of heme b 2; high-spin (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 405 | Fe (UniProtKB | ChEBI) of heme b 1; low-spin (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation | |
Biological Process | respiratory electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecytochrome-c oxidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Pseudorhodobacter
Accessions
- Primary accessionA0A4P8EGY5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 30-48 | Helical | |||
Transmembrane | 68-95 | Helical | |||
Transmembrane | 115-137 | Helical | |||
Transmembrane | 149-172 | Helical | |||
Transmembrane | 188-206 | Helical | |||
Transmembrane | 218-242 | Helical | |||
Transmembrane | 262-283 | Helical | |||
Transmembrane | 295-312 | Helical | |||
Transmembrane | 332-352 | Helical | |||
Transmembrane | 364-380 | Helical | |||
Transmembrane | 400-423 | Helical | |||
Transmembrane | 443-463 | Helical | |||
Transmembrane | 492-514 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-533 | Cytochrome oxidase subunit I profile | |||
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length533
- Mass (Da)59,682
- Last updated2019-07-31 v1
- ChecksumA0501506EC171C34
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP039964 EMBL· GenBank· DDBJ | QCO56002.1 EMBL· GenBank· DDBJ | Genomic DNA |