A0A4P7QH60 · A0A4P7QH60_9CORY
- ProteinD-alanine--D-alanine ligase
- Geneddl
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids362 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cell wall formation.
Catalytic activity
- ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H+ + phosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium or manganese ions per subunit.
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 17 | |||||
Sequence: E | ||||||
Binding site | 140 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 179-181 | ATP (UniProtKB | ChEBI) | ||||
Sequence: FVK | ||||||
Active site | 187 | |||||
Sequence: S | ||||||
Binding site | 187-188 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SS | ||||||
Binding site | 217-224 | ATP (UniProtKB | ChEBI) | ||||
Sequence: ESEITGSE | ||||||
Binding site | 303 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 314-315 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NE | ||||||
Binding site | 315 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 315 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 317 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 326 | |||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | D-alanine-D-alanine ligase activity | |
Molecular Function | metal ion binding | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameD-alanine--D-alanine ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium
Accessions
- Primary accessionA0A4P7QH60
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 144-348 | ATP-grasp | ||||
Sequence: KKLLAAEGLPVAPEVILRDRSELTEAEKALLGLPVFVKPARAGSSIGVSKVTDWSQLEGAVRLAHGADTKVLVESEITGSEVEIGVLQYPDGSLRASVPARLVGIEDSEEGFYGFETKYIDDVVSAEIPAQFDAGLVEQLQEMALEAFTALNCSGLSRVDFFVTDKGPVINEINTLPGFTPISMYPQVWAASGVGYSELLTLLIE |
Sequence similarities
Belongs to the D-alanine--D-alanine ligase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length362
- Mass (Da)38,357
- Last updated2019-07-31 v1
- Checksum93950572B658EE9D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP039247 EMBL· GenBank· DDBJ | QCB28326.1 EMBL· GenBank· DDBJ | Genomic DNA |