A0A4P6UZI7 · A0A4P6UZI7_9HYPH

Function

function

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

Catalytic activity

Features

Showing features for binding site.

1953100200300400500600700800900
TypeIDPosition(s)Description
Binding site605ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaminoacyl-tRNA editing activity
Molecular FunctionATP binding
Molecular Functionvaline-tRNA ligase activity
Biological Processvalyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Valine--tRNA ligase
  • EC number
  • Alternative names
    • Valyl-tRNA synthetase
      (ValRS
      )

Gene names

    • Name
      valS
    • ORF names
      E0E05_08015

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MA7-20
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Ahrensiaceae > Roseitalea

Accessions

  • Primary accession
    A0A4P6UZI7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, motif, coiled coil.

Type
IDPosition(s)Description
Domain15-642Aminoacyl-tRNA synthetase class Ia
Motif45-55'HIGH' region
Motif602-606'KMSKS' region
Domain684-825Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Coiled coil884-918
Domain886-946Valyl-tRNA synthetase tRNA-binding arm

Domain

The C-terminal coiled-coil domain is crucial for aminoacylation activity.
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    953
  • Mass (Da)
    106,727
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    76EC7F41A2DE292415ADE57DE7C386B2
MLDKTFDAARVEPRIAETWDAANAFAAGAGAREGAKPYCIVIPPPNVTGSLHMGHALNNTLQDVLIRHQRMLGNNVLWQPGMDHAGIATQMVVERQLAESGENMTRRQMGRDKFIERVWQWKDESGGQIFNQLKRLGASCDWSRERFTMDDGLSEAVLEVFVRLYKEGLIYRGKRLVNWDPKFETAISDLEVENIEVDGHMWHFKYPLADGATYEYVERDADGTVTLRETRDYISIATTRPETMLGDGAVAVHPSDERYAPIVGKLCEIPVGPKEHRRLIPIITDDYPDPDFGSGAVKITGAHDFNDYEVAKRGSIPMYRLMDTKAAMRDDGAPYAEAATIAQAVARGERTLNEAEADALNLVPDDLRGLDRFEARKRVVEQITGEGLAVMTTDDQGNAIPLVEAKRIMQPFGDRSHVVIEPMLTDQWFVDAKTLAEPAIASVREGRTQFVPRNWEKTYFEWMENIQPWCVSRQLWWGHRIPAWYGPDGTVFVAKTPDEAEAEARAHYGDDVDLTRDEDVLDTWFSSALWPFSTLGWPDKTEALDTWYPTSVLVTGFDIIFFWVARMMMMGLHFMKDDQGRGVEPFHTVYVHALVRDKHGAKMSKSKGNVIDPLELIDDYGADALRFTLAIMAAQGRDVKLDPARIAGYRNFGTKLWNATRFAQMNGVAHDAGFRPEDTKLTINRWILTEFGRTVTEVTEAIAAYRFNEAAGALYRFVWNTFCDWYLELLKPVFGGEDESAKAEARACAAFALDEIYKLLHPFMPFITEELWALTGKREGLICHAVWPEPVLADEAAADEINWLVELVSGVRSVRAEMNVPPSATGPLVVVGADETTTAWLLRHDPAIKQLARADDVVVAGEAPRGAAQIVVREATVCLPLGGLIDIAAEKARLEKAIAKAREEIVRLEKKLANDKFVANAKPEVVQAERDKLAEAVPALEKLQAAHARIVEM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036532
EMBL· GenBank· DDBJ
QBK30547.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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