A0A4P6UZ80 · A0A4P6UZ80_9HYPH

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site133(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site137-139(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site241Plays an important role in substrate specificity
Binding site257(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      E0E05_06955

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MA7-20
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Ahrensiaceae > Roseitalea

Accessions

  • Primary accession
    A0A4P6UZ80

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue242N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-397Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    46,253
  • Last updated
    2019-07-31 v1
  • Checksum
    C0F2C8AEFC689ACA
MSTDSAAAPHLSDAFFGDDLASCDPEIAGAIGKELGRQQQEIELIASENIVSRAVLEAQGSVMTNKYAEGYPGRRYYGGCQYVDIAEELAIDRAKELFGCGFANVQPNSGSQANQAVMLALAKPGDTILGMSLDAGGHLTHGARPNMSGKWFNAVQYGLDLDTGLIDYDQVAALAEEHKPRLIIAGGSAYSRVIDFARFRKIADAVGAHLWVDMAHFAGLVAAGVHPSPFPHAHVATTTTHKTLRGPRGGMVLTNDEDIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKSYMNAVAENAKVLAQTVIEGGMEIVSGGTDTHLMLVDLRPKGVTGKAAETALGRAFITCNKNGVPNDPQKPAITSGIRLGTPAATTRGFGPAEFREVGRLIVRVVDGLAQAGDEGDTSGIEDAVKAEVVELTRRFPIYPHLN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036532
EMBL· GenBank· DDBJ
QBK30361.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp