A0A4P6UY36 · A0A4P6UY36_9HYPH

  • Protein
    dITP/XTP pyrophosphatase
  • Gene
    rdgB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14-19substrate
Binding site46Mg2+ (UniProtKB | ChEBI)
Active site75Proton acceptor
Binding site75Mg2+ (UniProtKB | ChEBI)
Binding site76substrate
Binding site163-166substrate
Binding site186substrate
Binding site199-200substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      E0E05_01560

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MA7-20
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Ahrensiaceae > Roseitalea

Accessions

  • Primary accession
    A0A4P6UY36

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    23,108
  • Last updated
    2019-07-31 v1
  • Checksum
    3FAAF90E23ED316F
MTRRLEPGRLVLATHNDGKLREMRGLIGPFGFDVVSAGELGLAEPDEDGTTFEQNARTKAMAAMQASGLPALADDSGICVEALDGAPGVYTADWAETGNGRDFMMAMRTVEEKLQAAGATAPDERRAAFVAVLCLAFPDGHCEFFRGEAPGHLVWPPRGDLGFGYDPVFVPDGHDRTFGEMTADEKHGWTPGDAEALSHRARAFRLFAHDCLGVT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036532
EMBL· GenBank· DDBJ
QBK29393.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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