A0A4P6UW66 · A0A4P6UW66_9HYPH

Function

function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site215[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site222[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site225[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site231[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA N-glycosylase activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair, AP site formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III
  • EC number
  • Alternative names
    • DNA-(apurinic or apyrimidinic site) lyase

Gene names

    • Name
      nth
    • ORF names
      E0E05_01260

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MA7-20
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Ahrensiaceae > Roseitalea

Accessions

  • Primary accession
    A0A4P6UW66

Proteomes

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-30Disordered
Domain66-213HhH-GPD

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    253
  • Mass (Da)
    28,095
  • Last updated
    2019-07-31 v1
  • Checksum
    936DB38DF9E0C06F
MAVSQGKKPAAKSAGKAKKRARRLPRSKYSPDEVREIFRRFSVQRPEPKGELSHVNPYTLVVAVALSAQATDVGVNRATRDLFKVADTPEKMLALGEERVGEYIRTIGLWRNKAKNVIALSRKLVDEFGGEVPHTREKLMTLPGVGRKTANVVLQMAFGIPAIAVDTHIFRIANRIGLAPGKTPDEVEANLMRVIPDEYLLHAHHWLILHGRYTCKARKPDCVACVIADLCRYKDKTNAEPAPLIELPPQVIA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036532
EMBL· GenBank· DDBJ
QBK29342.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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