A0A4P6PBZ5 · A0A4P6PBZ5_9BACT

Function

function

APS kinase catalyzes the synthesis of activated sulfate.
Catalyzes the synthesis of activated sulfate.
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

Catalytic activity

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site37-44GTP (UniProtKB | ChEBI)
Binding site116-120GTP (UniProtKB | ChEBI)
Binding site171-174GTP (UniProtKB | ChEBI)
Binding site486-493ATP (UniProtKB | ChEBI)
Active site560Phosphoserine intermediate

GO annotations

AspectTerm
Molecular Functionadenylylsulfate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionsulfate adenylyltransferase (ATP) activity
Biological Processhydrogen sulfide biosynthetic process
Biological Processsulfate assimilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Sulfate adenylyltransferase subunit 1
  • EC number
  • Alternative names
    • ATP-sulfurylase large subunit
    • Sulfate adenylate transferase
      (SAT
      )
  • Recommended name
    Adenylyl-sulfate kinase
  • EC number
  • Alternative names
    • APS kinase
    • ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
    • Adenosine-5'-phosphosulfate kinase

Gene names

    • Name
      cysN
    • Synonyms
      cysC
    • ORF names
      EGM51_08065

Organism names

Accessions

  • Primary accession
    A0A4P6PBZ5

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Heterodimer composed of CysD, the smaller subunit, and CysN.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain28-254Tr-type G

Sequence similarities

Belongs to the APS kinase family.
In the C-terminal section; belongs to the APS kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    653
  • Mass (Da)
    72,676
  • Last updated
    2019-07-31 v1
  • Checksum
    2F939A077F58BC56
MTDPTYKIQEEELIRGNITEYLNRHETKDLLRILTCGSVDDGKSTLIGRLLYDSHMIYEDQLEKVAKDSKVYGTTDEEFDPALLTDGLKAEREQGITIDVAYRYFSTDKRKFIISDCPGHEQYTRNMATGASTCNLATILIDARHGVITQTKRHSFICSLLGIKHVVVAVNKMDLVDWSEEKYNEIVKDYNAFVARLGFSDIHFIPMSALKGDNVVEHSENLAWYDGPTFLHHLENVNISTDRNLIDMRFPIQYVLRPNLDFRGFSGTMASGVVRVGDEVASLPSRQTSRIKAIYGPDGQIEEAFADQAITVTLEDEIDVSRGNMLVPVNNVPHIGNEFEAMVVWMHEDAAKSGKSYLIKHTSSMVPGVLSSIRYKVDVNTMKRDKNEEDITSLELNEIGRCRLTLHRPIAFDPYEKNRTTGAFIIVDRLTNVTVGAGMIVDRIVSKPGHKKAPVSQNIVKSESLVSAADREGLLKQKGSTIWLTGLSGSGKSTIAQQLEKALIEQGHLCYILDGDNVRHGLNRDLGFSMEDRKENIRRIAEVAALMNDAGVIVITSFISPYISDRAAAREVIGDDSFIEVFVDTPLEVCEQRDPKGLYKKARSGEIPQFTGISDPYEAPESPEITIATERVEPDAAAGLIIGDLTSRGILGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036201
EMBL· GenBank· DDBJ
QBG47345.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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