A0A4P6KH97 · A0A4P6KH97_9MICO

  • Protein
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • Gene
    ispE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

Catalytic activity

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.

Features

Showing features for active site, binding site.

131020406080100120140160180200220240260280300
TypeIDPosition(s)Description
Active site16
Binding site102-112ATP (UniProtKB | ChEBI)
Active site144

GO annotations

AspectTerm
Molecular Function4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Molecular FunctionATP binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • EC number
  • Short names
    CMK
  • Alternative names
    • 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Gene names

    • Name
      ispE
    • ORF names
      EVS81_13180

Organism names

  • Taxonomic identifier
  • Strain
    • JW-1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Leucobacter

Accessions

  • Primary accession
    A0A4P6KH97

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain95-152GHMP kinase N-terminal
Domain217-292GHMP kinase C-terminal

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    31,775
  • Last updated
    2019-07-31 v1
  • Checksum
    24265905D4842D7A
MSTRGLRSITVRAPGKVNVFFRVGALQDDGYHDVASLYQAVSLFEEVTATEADDFSVRVTGPIDASGLPLDDRNLALRAAKLLAARTGTARGAALTVFKRVPIAGGMGGGSADAAATLVACDELWGTGLGRSGLLPLAAELGADVPFALEGGTAVGTGRGDELSPALAKGTFHWVLALSDNGLNTPVVYRALDRHRDEHLVDLGRQPDLVKVDTAVLQAVRVGDAGSLAEAMHNDLQVAALKLAPELTDLLELGETRGALAGIVSGSGPTVAFLVDSAQTAAELRSALTRGGVQALTVTGPVPGARVLDG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP035806
EMBL· GenBank· DDBJ
QBE49660.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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