A0A4P6KH97 · A0A4P6KH97_9MICO
- Protein4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
- GeneispE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids310 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Catalytic activity
- 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H+
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity | |
Molecular Function | ATP binding | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | terpenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
- EC number
- Short namesCMK
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Leucobacter
Accessions
- Primary accessionA0A4P6KH97
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 95-152 | GHMP kinase N-terminal | ||||
Sequence: LTVFKRVPIAGGMGGGSADAAATLVACDELWGTGLGRSGLLPLAAELGADVPFALEGG | ||||||
Domain | 217-292 | GHMP kinase C-terminal | ||||
Sequence: LQAVRVGDAGSLAEAMHNDLQVAALKLAPELTDLLELGETRGALAGIVSGSGPTVAFLVDSAQTAAELRSALTRGG |
Sequence similarities
Belongs to the GHMP kinase family. IspE subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length310
- Mass (Da)31,775
- Last updated2019-07-31 v1
- Checksum24265905D4842D7A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP035806 EMBL· GenBank· DDBJ | QBE49660.1 EMBL· GenBank· DDBJ | Genomic DNA |