A0A4P6KD85 · A0A4P6KD85_9MICO
- ProteinDiaminopimelate epimerase
- GenedapF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids291 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Catalytic activity
- (2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14 | substrate | ||||
Sequence: N | ||||||
Binding site | 78 | substrate | ||||
Sequence: N | ||||||
Active site | 87 | |||||
Sequence: C | ||||||
Active site | 87 | Proton donor | ||||
Sequence: C | ||||||
Binding site | 88-89 | substrate | ||||
Sequence: GN | ||||||
Binding site | 163 | substrate | ||||
Sequence: N | ||||||
Site | 165 | Could be important to modulate the pK values of the two catalytic cysteine residues | ||||
Sequence: H | ||||||
Binding site | 196 | substrate | ||||
Sequence: N | ||||||
Site | 220 | Could be important to modulate the pK values of the two catalytic cysteine residues | ||||
Sequence: E | ||||||
Binding site | 220-221 | substrate | ||||
Sequence: ER | ||||||
Active site | 229 | Proton acceptor | ||||
Sequence: C | ||||||
Binding site | 230-231 | substrate | ||||
Sequence: GT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | diaminopimelate epimerase activity | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate epimerase
- EC number
- Short namesDAP epimerase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Leucobacter
Accessions
- Primary accessionA0A4P6KD85
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length291
- Mass (Da)31,339
- Last updated2019-07-31 v1
- ChecksumBE011F0E469E52B4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP035806 EMBL· GenBank· DDBJ | QBE47871.1 EMBL· GenBank· DDBJ | Genomic DNA |