A0A4P6KD85 · A0A4P6KD85_9MICO

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site14substrate
Binding site78substrate
Active site87
Active site87Proton donor
Binding site88-89substrate
Binding site163substrate
Site165Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site196substrate
Site220Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site220-221substrate
Active site229Proton acceptor
Binding site230-231substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondiaminopimelate epimerase activity
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      dapF
    • ORF names
      EVS81_02705

Organism names

  • Taxonomic identifier
  • Strain
    • JW-1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Leucobacter

Accessions

  • Primary accession
    A0A4P6KD85

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    291
  • Mass (Da)
    31,339
  • Last updated
    2019-07-31 v1
  • Checksum
    BE011F0E469E52B4
MTTLSFTKGHGTGNDFVLFTDPQGELTLSPEQIRFLCDRRFGVGADGVIRAVRSRAIPEGAAILEEEPEAEWFMDYWNADGTPAEMCGNGIRVYAHYLVSEGLVTPERRDTLPIGTRAGVKDVLAGVSGYTVDLGRWRLAEERLVAAYGLDVARPGLGIDLGNPHVVTALAHVGELESLDLHRAPTLDPAPAEGANVEFVVPEEPLVKDGVARIRMRVYERGVGETLSCGTGTAAAALAFRHWGGDGMPNHWSVEVPGGRLAVRMFPTEEGEHVSLNGPAELVYSGEIELP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP035806
EMBL· GenBank· DDBJ
QBE47871.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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