A0A4P6KB67 · A0A4P6KB67_9MICO

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

132650100150200250300
TypeIDPosition(s)Description
Binding site54carbamoyl phosphate (UniProtKB | ChEBI)
Binding site55carbamoyl phosphate (UniProtKB | ChEBI)
Binding site82L-aspartate (UniProtKB | ChEBI)
Binding site104carbamoyl phosphate (UniProtKB | ChEBI)
Binding site134carbamoyl phosphate (UniProtKB | ChEBI)
Binding site137carbamoyl phosphate (UniProtKB | ChEBI)
Binding site182L-aspartate (UniProtKB | ChEBI)
Binding site238L-aspartate (UniProtKB | ChEBI)
Binding site279carbamoyl phosphate (UniProtKB | ChEBI)
Binding site280carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • ORF names
      EVS81_00225

Organism names

  • Taxonomic identifier
  • Strain
    • JW-1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Leucobacter

Accessions

  • Primary accession
    A0A4P6KB67

Proteomes

Subcellular Location

Interaction

Subunit

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-146Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain168-317Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    326
  • Mass (Da)
    35,535
  • Last updated
    2019-07-31 v1
  • Checksum
    4B6963B664891E73
MRHLLDTRTLSRDDAIRILDTAEDMAAAQQREVKKLPALRGKTVVNLFYEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTAQTLQAIGADGVVIRHPASGAPERLARSGWIDAGVLNAGDGTHEHPTQALLDAFTMRRRLFGSGAGVSDASGSRGRDLDGVSVAIVGDVAHSRVARSNLWLLNALGAHVTFVAPETLLPYGARDWPVKIHHSLDAALRDERPEVVMMLRIQSERMHAAFFPNEREYARNWGLDDARLERLVDEAIVMHPGPMNRGLEISSRAADSERSTVLEQVANGVSVRMAALYLLLSGEREASI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP035806
EMBL· GenBank· DDBJ
QBE47457.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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