MK2 is a serine/threonine kinase that functions downstream of p38 stress-activated mitogen-activated protein kinase with a role in experimental colitis
The MK2/3 are the only LPS-induced kinases for S52 and S178 of TTP and the role of MK2 and MK3 in the regulation of TNF biosynthesis is not restricted to phosphorylation of TTP at S52/S178 but includes independent processes which could involve other TTP phosphorylations.
This is the first study to demonstrate the critical role of the MK2 pathway in chemokine production macrophage influx macrophage function and tumor growth.
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