A0A4P2USK8 · A0A4P2USK8_CYRTA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • UF441144
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Palaeoheterodonta > Unionida > Unionoidea > Unionidae > Ambleminae > Lampsilini > Cyrtonaias

Accessions

  • Primary accession
    A0A4P2USK8

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane46-72Helical
Transmembrane84-102Helical
Transmembrane122-146Helical
Transmembrane167-194Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_503382986019-219Cytochrome c oxidase subunit 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,276
  • Last updated
    2019-07-31 v1
  • Checksum
    5A8205BDCE006EDC
TLYLLFALWSGLIGLALSLLIRAELGQPGSLLGDDQLYNVIVTAHAFMMIFFLVMPMMIGGFGNWLIPLMIGAPDMAFPRLNNLSFWLLVPALFLLLSSSLVESGVGTGWTVYPPLSGNVAHSGASVDLAIFSLHLAGASSILGAINFISTVGNMRSPGVVAERIPLFVWAVTVTAVLLVAALPVLAGAITMLLTDRNINTSFFDPVGGGDPILYMHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK044906
EMBL· GenBank· DDBJ
AZI71108.1
EMBL· GenBank· DDBJ
Genomic DNA
MT553984
EMBL· GenBank· DDBJ
QOE31739.1
EMBL· GenBank· DDBJ
Genomic DNA
MT553985
EMBL· GenBank· DDBJ
QOE31740.1
EMBL· GenBank· DDBJ
Genomic DNA
MT553986
EMBL· GenBank· DDBJ
QOE31741.1
EMBL· GenBank· DDBJ
Genomic DNA
MT553987
EMBL· GenBank· DDBJ
QOE31742.1
EMBL· GenBank· DDBJ
Genomic DNA
MT553988
EMBL· GenBank· DDBJ
QOE31743.1
EMBL· GenBank· DDBJ
Genomic DNA
MT553989
EMBL· GenBank· DDBJ
QOE31744.1
EMBL· GenBank· DDBJ
Genomic DNA
MT553991
EMBL· GenBank· DDBJ
QOE31746.1
EMBL· GenBank· DDBJ
Genomic DNA
MT553992
EMBL· GenBank· DDBJ
QOE31747.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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