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A0A4P1TJU5 · A0A4P1TJU5_CYPVA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Cyprinodontiformes > Cyprinodontidae > Cyprinodon

Accessions

  • Primary accession
    A0A4P1TJU5

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane36-58Helical
Transmembrane92-112Helical
Transmembrane132-154Helical
Transmembrane166-193Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-217Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    217
  • Mass (Da)
    23,133
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    8AC199A2DE289950E33C8795F3D1C695
LYLVFGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue217

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU806961
EMBL· GenBank· DDBJ
ADH42761.1
EMBL· GenBank· DDBJ
Genomic DNA
GU806962
EMBL· GenBank· DDBJ
ADH42762.1
EMBL· GenBank· DDBJ
Genomic DNA
GU806963
EMBL· GenBank· DDBJ
ADH42763.1
EMBL· GenBank· DDBJ
Genomic DNA
GU806964
EMBL· GenBank· DDBJ
ADH42764.1
EMBL· GenBank· DDBJ
Genomic DNA
GU806966
EMBL· GenBank· DDBJ
ADH42766.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573256
EMBL· GenBank· DDBJ
ADQ98487.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573257
EMBL· GenBank· DDBJ
ADQ98488.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573258
EMBL· GenBank· DDBJ
ADQ98489.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573259
EMBL· GenBank· DDBJ
ADQ98490.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573260
EMBL· GenBank· DDBJ
ADQ98491.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573340
EMBL· GenBank· DDBJ
ADQ98571.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573357
EMBL· GenBank· DDBJ
ADQ98588.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573358
EMBL· GenBank· DDBJ
ADQ98589.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573359
EMBL· GenBank· DDBJ
ADQ98590.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573360
EMBL· GenBank· DDBJ
ADQ98591.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ573361
EMBL· GenBank· DDBJ
ADQ98592.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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