A0A4E9EIW8 · A0A4E9EIW8_GIBZA

Function

function

Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Release of an N-terminal tripeptide from a polypeptide.
    EC:3.4.14.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

115772004006008001,0001,2001,400
TypeIDPosition(s)Description
Active site284Charge relay system
Active site288Charge relay system
Active site505Charge relay system
Binding site548Ca2+ (UniProtKB | ChEBI)
Binding site549Ca2+ (UniProtKB | ChEBI)
Binding site573Ca2+ (UniProtKB | ChEBI)
Binding site575Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular Functionserine-type endopeptidase activity
Molecular Functiontransferase activity
Molecular Functiontripeptidyl-peptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tripeptidyl-peptidase II
  • EC number

Gene names

    • ORF names
      FUG_LOCUS477686
      , MDCFG202_LOCUS307022

Organism names

Accessions

  • Primary accession
    A0A4E9EIW8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_504108628019-1577tripeptidyl-peptidase II

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain206-595Peptidase S53
Domain624-1218Deacetylase sirtuin-type
Region683-876Disordered
Compositional bias689-725Basic and acidic residues
Compositional bias764-779Polar residues
Compositional bias837-873Polar residues
Region982-1009Disordered
Region1207-1232Disordered
Compositional bias1211-1232Basic and acidic residues
Region1304-1358Disordered
Compositional bias1325-1343Polar residues
Compositional bias1344-1358Basic and acidic residues
Region1393-1432Disordered
Compositional bias1417-1432Pro residues

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,577
  • Mass (Da)
    173,513
  • Last updated
    2020-08-12 v1
  • Checksum
    25A4BF05D16D9D9A
MISPILFTTLALAGLGAAKNIKVEETPVLPNGWEKVNQAVDPSHVLRLSIAMRQPDIENLKTGLRKRDATSGQYIQRHLCQQEALALRTPDKKDVDKVLAWLKSKGAAAKATPDKDWIHVKTTVKDAQDLLDAKIGFYQFADQEPVLRTRDYSLPESLVNSISFIHPIANFMRPVKELTTPDPDFTPSMLKSLQLDKRASIPCGQAIKPDCLREQFNITYPAYNGTSPIRFGIAGFLEEYANYEDAQDFLRIYAKPLYEARYNFSVQLINGANNSQDLFDSGNEAALDVQYAMALGYPTNITYYLADGRGPTLDDDGEQVSEEYNDNEPYLEFLDYLLDLSDDEVPHVLSVSYGDNEVSVPRKYAERVCSMFGLLTARGTTILAASGDGGAKGSSNSTCRTNDGSHKDVTMAVFPATCPWVTSVGGVAAGAAPFEGAEFSGGGFSQYFPREKWQESSIKSYVKTLDGHLDGNYNASNRGVPDISMPATSYITRLKGQQVALRGTSASTPVMAAMIALINDARVRKGKNVLGWINEVLYSDKVQAALSDVTAGESRPCDFQKGHSPAGWPAAKGWDAITGLGVPSDFQKLCRLHAIAAYNRPLQYRDAADFPSSFSSTMPTTHVAPESQDELRDIANGLLKARKVIVVTGAGISTNSGIPDFRSENGLYSLISTQLDAAQQARLQENTANDEPSDSDSRPAPKRRKILRDECLKLEQDSGETKDEIEVQLEDPDPVEEKVADSIQVEGDHEDEDQPEDPDAVPSINPRTTRSTIAVAQPPTSPLSSPPPEDFRITPPSVFRRARRSHLHDSEIPPSSSPLSSPPPVLFEPFSSHASEEDGPGSRSSTSPSEVDDTPPSLPPNLSQTNLGTGKNTLPNMKGKDMFDASIWADPLRTSVFYTFATTLRQKVRDVEPTSSHRFISHLRDRGKLVRCYTQNIDQIEEKVGLSTCLTDGPGSRGRFSRKSTANLNQLNRMVDEANAMTEANSDRSQPPSDNEASQQSQPSQSRPDIMMASQAESDTGAPEDAMTAVENLRRDLPKSGVECVFLHGSLELLRCFLCGRVCSWDDNGRQLETMSGQQPECPHCVGATVAREERGKRPLGVGKLRPDIVLYGEEHPNAHLISPIVTHDLALCPDLLLILGTSLRVHGLKVMVREFAKAVHAKGGKVVFVNYTKPPESSWGDVIDYWVEWDCDAWVSDLQEKIPKLWQTPDPPKLKKKRDSGGVGEEGEKMDAKRCTAANPIALRDTKATGAYWVSKIMRELHRITGHGPLDPREIVTPVIVAAPIEIPTVPAEPEPVEVLQNKPIAIPKRSKRSRKSAPSTLERCKKPPSTLNPNHGRTLRSTETAEPPKVEEAEIPFSHILRPERFIKESSIIDSVKGRVRKRRRIDGEEVELPSVGRRQSSQKPPEIDNSLRLPPMKPQPPTPHNSPPFERLAPMEPPHCETPPKYFINAQLQPVSPVAAPNPGPLKQVSHNTSRRVTRSQRSSMGLEEAPAPFVAGCPPPETALEWCYSHQGSYSLVRKTDYSPAETGAIAALSMLKQGEARNFVLSPQSRLSLSFDSLDAKTLLEKKYIRED

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias689-725Basic and acidic residues
Compositional bias764-779Polar residues
Compositional bias837-873Polar residues
Compositional bias1211-1232Basic and acidic residues
Compositional bias1325-1343Polar residues
Compositional bias1344-1358Basic and acidic residues
Compositional bias1417-1432Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJPIJ010000146
EMBL· GenBank· DDBJ
CAG1989100.1
EMBL· GenBank· DDBJ
Genomic DNA
CAAKMV010000163
EMBL· GenBank· DDBJ
VIO62747.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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