A0A4D7DXP9 · A0A4D7DXP9_9HYPH

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13-18substrate
Binding site45Mg2+ (UniProtKB | ChEBI)
Active site74Proton acceptor
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site75substrate
Binding site163-166substrate
Binding site186substrate
Binding site199-200substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      CFBP5473_14320

Organism names

  • Taxonomic identifier
  • Strain
    • CFBP5473
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Agrobacterium

Accessions

  • Primary accession
    A0A4D7DXP9

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    214
  • Mass (Da)
    23,113
  • Last updated
    2019-07-31 v1
  • Checksum
    462B5E10E62859E3
MRKLDTRTIVVASHNKGKIAEIADLIGPFGFSAKSAAELNFEEPDETGTTFEENAAIKALASAKASGLPALSDDSGLVIDALDGAPGVYTANWAETADGTRDFDMAMRKVEDALQERGATDPKDRTCRFVSVLCLAWPDGHTEFFRGEIEGTVAWPPRGASGFGYDPVFQPEGYETTFGEMTAQEKHGWKPGDADALSHRARAFKTFVETCLEA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP039691
EMBL· GenBank· DDBJ
QCI98966.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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