Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A4D6YB32 · A0A4D6YB32_9GAMM

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functiondihydrofolate synthase activity
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processfolic acid biosynthetic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase

Gene names

    • ORF names
      D9V81_00635

Organism names

Accessions

  • Primary accession
    A0A4D6YB32

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain53-235Mur ligase central
Domain288-408Mur ligase C-terminal

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    423
  • Mass (Da)
    48,891
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    61AE596B866A1BCB515035F07D648C9E
MKKYFFNEDILLIKWLKYIKKNCKKKYNFSMFNIIKVAKKLNILKLSSFVITVSGTNGKGSTCAILERCFLNSGYTVGLYTSPHLFNYYERIRINGKYIKKSFMHINAFLKVELARKNNQLTYFEFITLSALLLFKERNLNVIILEVGLGGRLDATNIINPNIAIITNIGLDHTSILGNSRDDIGYEKSGIFRKGIKVIIGDDNIPNSIYKMAYIFKVILYRKNYEWNWYELKNYWNFYDQYGILNNIPIPKVSFLSAAIAIAALRVSSFKIDKNVILKSINTVFLMGRFQIIYKKPIIIVDVAHNSDATFYLSQRLKKLLYIKGNIKLYALIGMLSKKDIKGTISSLINIIDYWYYTILNTHQTATINDLKKHLPKNAIYCISVKKALYQLIQKVQKNDIILIFGSFFTVSEAITAMRTLNL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP032996
EMBL· GenBank· DDBJ
QCI27127.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help