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A0A4D6YA34 · A0A4D6YA34_BUCMH

Function

function

Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

Catalytic activity

Features

Showing features for binding site.

143550100150200250300350400
TypeIDPosition(s)Description
Binding site19-24ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular FunctiontRNA(Ile)-lysidine synthase activity
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA(Ile)-lysidine synthase
  • EC number
  • Alternative names
    • tRNA(Ile)-2-lysyl-cytidine synthase
    • tRNA(Ile)-lysidine synthetase

Gene names

    • Name
      tilS
    • ORF names
      D9V73_00520

Organism names

Accessions

  • Primary accession
    A0A4D6YA34

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain357-429Lysidine-tRNA(Ile) synthetase C-terminal

Domain

The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

Sequence similarities

Belongs to the tRNA(Ile)-lysidine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    435
  • Mass (Da)
    51,280
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    1D7B702EF753703B29CCC733A2B25AA6
MITKYIKKISGLSFLLAYSGGLDSTFLFYQLLKAKKVQPKLKFRAIHINHQLNKNSNEWNRHCRQVCEKHNITLIEKKTIINKKKLGIEAAARLKRYEIICNEALPTEIILTAHNLNDQCETLFLALKRGSGITGLSGMSYKSKLFNKYIIIRPLLNIDRSEIQSWISKNNIHWIEDTSNYDTTYDRNFLRHKILPLFTKRWPNFIEKCATSTCILKKEKSILDQILEKKLNKYLICNSILNITDFAEMKSEIRYSLLRKWIQINNYTAPSYKIIKAIYYEVILSKPDSKAKVKVNNQEIKRYKQNLYFVKIVPCIKNLILMWYPPWNYLKLPNNLGFIIQNKFGIVLPVPKKNEIVNIRFQTSGKVLIQGNPIRKKIKKIWQEHKINPWNRTNIPLLFYNNTLISALGIFNVIHDDRKQSEHTWTLSWINNIHN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP033004
EMBL· GenBank· DDBJ
QCI23141.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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