A0A4D6XYI2 · A0A4D6XYI2_9GAMM
- ProteinNAD kinase
- GenenadK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids292 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalytic activity
- NAD+ + ATP = ADP + NADP+ + H+
Cofactor
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 73 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 73-74 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DG | ||||||
Binding site | 147-148 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NE | ||||||
Binding site | 158 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 175 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 177 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 188-193 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TGYSLS | ||||||
Binding site | 247 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | NAD binding | |
Molecular Function | NAD+ kinase activity | |
Biological Process | NAD metabolic process | |
Biological Process | NADP biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Buchnera
Accessions
- Primary accessionA0A4D6XYI2
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length292
- Mass (Da)32,497
- Last updated2019-07-31 v1
- Checksum779AA150E23EF964