A0A4D6XXW0 · A0A4D6XXW0_9GAMM
- ProteinDihydrolipoyl dehydrogenase
- GenelpdA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids476 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activity
- N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N6-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 54 | FAD (UniProtKB | ChEBI) | |||
Binding site | 117 | FAD (UniProtKB | ChEBI) | |||
Binding site | 182-189 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 272 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 313 | FAD (UniProtKB | ChEBI) | |||
Binding site | 319-322 | FAD (UniProtKB | ChEBI) | |||
Active site | 445 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dihydrolipoyl dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydrolipoyl dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Buchnera
Accessions
- Primary accessionA0A4D6XXW0
Proteomes
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 45↔50 | Redox-active | |||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 8-328 | FAD/NAD(P)-binding | |||
Domain | 347-452 | Pyridine nucleotide-disulphide oxidoreductase dimerisation | |||
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)52,214
- Last updated2019-07-31 v1
- ChecksumF947072E5195C16E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP033012 EMBL· GenBank· DDBJ | QCI19298.1 EMBL· GenBank· DDBJ | Genomic DNA |