A0A4D6Q2N8 · A0A4D6Q2N8_9ERIC

  • Protein
    NADH-quinone oxidoreductase subunit A
  • Gene
    ndhC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentchloroplast
Cellular Componentmitochondrial membrane
Cellular ComponentNADH dehydrogenase complex
Cellular Componentplasma membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit A
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit A
    • NDH-1 subunit A
    • NUO1

Gene names

    • Name
      ndhC
    • Synonyms
      nuoA

Encoded on

  • Plastid

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > Ericales > Ericaceae > Vaccinioideae > Vaccinieae > Vaccinium

Accessions

  • Primary accession
    A0A4D6Q2N8

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-34Helical
Transmembrane62-83Helical
Transmembrane89-112Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Family & Domains

Sequence similarities

Belongs to the complex I subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    120
  • Mass (Da)
    13,858
  • Last updated
    2019-07-03 v1
  • Checksum
    67E01A5BDF93DAF8
MFLLYEYDIFWTFLLISSLIPVLAFLISGVLAPLSKGPEKLSIYESGIEPVGDAWLQFQIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSVFIEAFIFVLILIVGSVYAWRKGALEWF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK049537
EMBL· GenBank· DDBJ
QCF39501.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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