A0A4D6IYA1 · A0A4D6IYA1_9AVES

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 1A
    • C4
    • P1
    • P2
    • P3
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Accipitriformes > Accipitridae > Clanga

Accessions

  • Primary accession
    A0A4D6IYA1

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane33-58Helical
Transmembrane79-101Helical
Transmembrane121-146Helical
Transmembrane158-185Helical
Transmembrane205-226Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-228Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    228
  • Mass (Da)
    24,394
  • Last updated
    2019-07-03 v1
  • Checksum
    8DE851B1341E795F
AGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTVEAGAGTGWTVYPPLAGNMAHAGASVDLAIFSLHLAGISSILGAINFITTAINMKPPALSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue228

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK292290
EMBL· GenBank· DDBJ
QCC72989.1
EMBL· GenBank· DDBJ
Genomic DNA
MK292291
EMBL· GenBank· DDBJ
QCC72990.1
EMBL· GenBank· DDBJ
Genomic DNA
MK292292
EMBL· GenBank· DDBJ
QCC72991.1
EMBL· GenBank· DDBJ
Genomic DNA
MK292293
EMBL· GenBank· DDBJ
QCC72992.1
EMBL· GenBank· DDBJ
Genomic DNA
MK292294
EMBL· GenBank· DDBJ
QCC72993.1
EMBL· GenBank· DDBJ
Genomic DNA
MK292295
EMBL· GenBank· DDBJ
QCC72994.1
EMBL· GenBank· DDBJ
Genomic DNA
MK292296
EMBL· GenBank· DDBJ
QCC72995.1
EMBL· GenBank· DDBJ
Genomic DNA
MK292297
EMBL· GenBank· DDBJ
QCC72996.1
EMBL· GenBank· DDBJ
Genomic DNA
MK292298
EMBL· GenBank· DDBJ
QCC72997.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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