A0A4D6IA61 · KABC_DIGSM

Function

function

Iron/ascorbate-dependent oxidoreductase: part of the gene cluster that mediates the biosynthesis of kainic acid (KA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins (PubMed:30995339).
Catalyzes the conversion of prekainic acid to kainic acid and kainic acid lactone (PubMed:30995339).

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Activity regulation

Inhibited by the iron chelator EDTA.

Biotechnology

Escherichia coli cells expressing Digenea simplex kabC are successfully converting supplied synthetic prekainic acid into kainic acid, thus providing a less expensive method to produce this molecule for neuro-pharmacological applications.

Pathway

Secondary metabolite biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site225Fe cation (UniProtKB | ChEBI)
Binding site227Fe cation (UniProtKB | ChEBI)
Binding site286Fe cation (UniProtKB | ChEBI)
Binding site3012-oxoglutarate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function2-oxoglutarate-dependent dioxygenase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-ketoglutarate dependent kainoid synthase
  • EC number
  • Short names
    Alpha-KG dependent kainoid synthase
  • Alternative names
    • Kainic acid biosynthesis cluster protein C
      (DsKabC
      )

Gene names

    • Name
      kabC

Organism names

Accessions

  • Primary accession
    A0A4D6IA61

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004542721-360Alpha-ketoglutarate dependent kainoid synthase

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain200-310Fe2OG dioxygenase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    360
  • Mass (Da)
    41,163
  • Last updated
    2019-07-03 v1
  • Checksum
    BD06A2E1FAAD0F22
MTVSKYNGVASTFNGVARRFDFAPLEADKLNWYPRSALPPEIPAIDLNKVNTEEELAQFLVDIRKSGLFYIVDHGIPEEISIGCYNAFREFCNLPEEAREKYNTDESFKSGGYVPFKGTSIGGGNLFERQKDFVVKFFWRGPSVVNRSPNDRFAEFHDEHHRKTAELAEKIITTILKALKTRFPEFHPDELKDNINVRNMFFSNRIYPEAPPDDGEKADYRLVPHRDLSFITLANQVPANNGFKGLFILTGDGEKIPVPPIRNSYLVFIGQGLSYLTNKYLPAALHGVDFPDNTNFEGSERASLISFYEPNDYMMPSKNINPLPEEIFEKSCTFYDDVGVGRAGTTYNYVRYKFHEGYYL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK312630
EMBL· GenBank· DDBJ
QCC62383.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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