A0A4D6HP01 · A0A4D6HP01_9EURY

Function

function

Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionexonuclease activity
Molecular Functionphosphoric ester hydrolase activity
Molecular Functionzinc ion binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase beta
  • EC number
  • Alternative names
    • 5'-deoxyribose-phosphate lyase
    • AP lyase

Gene names

    • ORF names
      DV706_11110

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM 10635
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Natrialbaceae > Natronorubrum

Accessions

  • Primary accession
    A0A4D6HP01

Proteomes

Subcellular Location

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-327DNA-directed DNA polymerase X
Domain54-73Helix-hairpin-helix DNA-binding motif class 1
Domain94-113Helix-hairpin-helix DNA-binding motif class 1
Domain129-148Helix-hairpin-helix DNA-binding motif class 1
Domain351-431Polymerase/histidinol phosphatase N-terminal

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    583
  • Mass (Da)
    62,950
  • Last updated
    2019-07-03 v1
  • Checksum
    A86BC270D38C93CC
MATNAEIAGRFEEFADLLEADDVEYKPRAYRRAAENIRAHPVPISDPVASGNEDVLEEIDGVGDAISAKIVEYVETGTIEELEELRAELPIDIADITRIEGVGPKTAGKLYRELGVESLDALEAAAEAGDVQEIKGFGPKTEQNIRDNLEFARQIGQRYLLGEGRPLADDVLAFLEGLEAVERCEVAGSIRRWRETIGDVDVLAATDAGEDVVEAFVDWESVDGEIESGPEKASVRVGEIRVDLRVVVPEEFGSALQYFTGSKDHNVRLRNYAIDRGMKLNEYGAFDVSEIDAPDAGLRVGDRVAGDTEAGMYEALGLPWIPPELREDRGEIAAAENDALPDLLTRADIQGDLHTHTEWSDGNTSLEAMVEAATELGYEYYGVADHAEGPGIVGGMGLSNAEILGQVELVRELDADSEIAVFAGIEANVDADGEIGLSEDVIDALDVVVASPHSGLDQDAQTATDRLVRAIENPAVDVLGHPSGRLLNERSGLEFDATALGEAAAANDTALEINANPRRLDLWGSAVQAALEKGAPIAVNTDAHQPSTLEYMRWGVHTARRGWAEPDDVINTWGLEELRAFLH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP031305
EMBL· GenBank· DDBJ
QCC54966.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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