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A0A4D6HN59 · A0A4D6HN59_9EURY

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      DV706_09685

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM 10635
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Natrialbaceae > Natronorubrum

Accessions

  • Primary accession
    A0A4D6HN59

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane52-72Helical
Transmembrane79-98Helical
Transmembrane104-126Helical
Transmembrane138-160Helical
Transmembrane166-188Helical
Transmembrane226-249Helical
Transmembrane261-283Helical
Transmembrane295-314Helical
Transmembrane320-340Helical
Transmembrane352-377Helical
Transmembrane397-419Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-423Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    424
  • Mass (Da)
    45,328
  • Last updated
    2019-07-03 v1
  • MD5 Checksum
    54BF1B51D9BBE55B16AE583AF73359F2
MRLWADPLRRRWLLWATLGVVFLLVNMNRLSSAVLAEELMGAFETTGAQLGTLHAIFFWVYAIMQIPTGILADRIGPRRTATAGVAVMNVGVVWFAFADSYLTAIVARGLVGLGGSVIFVCILRFCANWYRADEFATMNGLTFAFSGFGGVLATTPLAILVDSAGWRTAIGGFGVVGLLFTVVVFALVRDTPTQAGFDPLEGVPGQSTLTNAQLKTSLSDILRDPLVWVVSVMLFCVTGVNLTLFGLWGVPYIVQIYDVSVTYASVFTLFGSVGIMIGPPAIGWLSDRLERRVELIVVGGGLFTGSLGIIAVFGDPPLPVVGLVYFLSGLLMGSFLLAYATVKDRHPANASGLSTGTINGASFFGAATLPTAMGWALDDYWAGDLVGGTRVYTEIGYQLAFAIATAAGAIAFLCAIWLYRHEQR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP031305
EMBL· GenBank· DDBJ
QCC54716.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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