A0A4D6HIF9 · A0A4D6HIF9_9EURY

  • Protein
    tRNA-guanine(15) transglycosylase
  • Gene
    tgtA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

tRNA modification; archaeosine-tRNA biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site93Nucleophile
Binding site128substrate
Binding site196substrate
Binding site279Zn2+ (UniProtKB | ChEBI)
Binding site281Zn2+ (UniProtKB | ChEBI)
Binding site284Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionpentosyltransferase activity
Molecular Functionzinc ion binding
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA wobble guanine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-guanine(15) transglycosylase
  • EC number
  • Alternative names
    • 7-cyano-7-deazaguanine tRNA-ribosyltransferase
    • Archaeal tRNA-guanine transglycosylase

Gene names

    • Name
      tgtA
    • ORF names
      DV706_03675

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM 10635
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Natrialbaceae > Natronorubrum

Accessions

  • Primary accession
    A0A4D6HIF9

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-340tRNA-guanine15 transglycosylase-like

Sequence similarities

Belongs to the archaeosine tRNA-ribosyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    493
  • Mass (Da)
    54,061
  • Last updated
    2019-07-03 v1
  • Checksum
    E6EB17D262B315CF
MRECFEVRDTDVGGRIGELTVPRADVTVETPALLPVINPNLDTIAPRRLATEFGAEILITNSYIIHGTDDVREQALEDGLHDLLDFPGAIMTDSGSFQLSEYGEIDVTTEEILEFQHAIGSDIATPVDIPTPPDVSRERAEDELATTQERLELADEIDTGEMLVSAPVQGSTYPDLREAAGRHADGTDLDVFPVGAVVPLMNDYRYDDMIDAVAAAKRGLGADAPVHLFGAGHPMMFALAAAMGCDLFDSAAYALYARDDRYLTVRGTRHLEDLDYLPCSCPVCTAHSPADLRALPDDEREEALAAHNLHVTFEEIRRIKQAIRAGNLLELVEQRARAHPTMLDGYRTLLDHAAQLERADPVSKGAFFYTSHESARRPEVLRHHQHLDRLSVPDSLFLTEGSSARGDEFDDSWRVKPPFGPFPRALSKSYPLTAEAPDRTDRAALEAAADGVTRLVESNPETEVTLGHKGWPAGVLETLPEEVALVDLTADRT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP031305
EMBL· GenBank· DDBJ
QCC53663.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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