A0A4D6GTS7 · A0A4D6GTS7_HALS9

Function

function

Essential for tRNA splicing and maturation. Acts by directly joining spliced tRNA halves to mature-sized tRNAs. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site100Mn2+ 1 (UniProtKB | ChEBI)
Binding site207-211GMP (UniProtKB | ChEBI)
Binding site208Mn2+ 1 (UniProtKB | ChEBI)
Binding site239Mn2+ 2 (UniProtKB | ChEBI)
Binding site334Mn2+ 2 (UniProtKB | ChEBI)
Binding site334-335GMP (UniProtKB | ChEBI)
Binding site396-399GMP (UniProtKB | ChEBI)
Binding site403GMP (UniProtKB | ChEBI)
Active site422GMP-histidine intermediate
Binding site422-425GMP (UniProtKB | ChEBI)
Binding site499GMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionRNA ligase (ATP) activity
Molecular FunctionRNA ligase (GTP) activity
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-splicing ligase RtcB
  • EC number

Gene names

    • Name
      rtcB
    • ORF names
      APQ99_02074
      , HBSAL_07820

Organism names

Accessions

  • Primary accession
    A0A4D6GTS7

Proteomes

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Belongs to the RtcB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    500
  • Mass (Da)
    52,845
  • Last updated
    2019-07-03 v1
  • Checksum
    0CE00E786FD0C961
MSTFDADGHRLTEVEPDVWALADTGDESVPARVLANRSLLAQISTDNTLTQLRNVAGMPGAVAPALCMPDGHQGYGFPVGGVAAFDAEDGCISPGGVGFDINCGVRMLTTTLTYDDVKGREAALVDALYDAVPCGLGGGGVHDGTHADLDAALERGIDWCVEEGYAVPADRRHCEDEGQRLDADLDAVSKKARDRGASQMGSLGSGNHFLEVQRVTDVYDDDTAAAFGLAEDQVVVLIHCGSRGLGHQICSDYLRRIEQEHPDFLASLPNKDLAAAPAGSELAASYYGAMCAAINFAWVNRQLITHAVRETFADVFDAPDWEALGMDLLYDVSHNIAKRETHAVVETEDGYSLAGDGERVERELFVHRKGATRAFPAGHPEVPAAYREVGQPVIIPGSMGAGSYVLRGGSQSLGRTFGSTAHGAGRLMSRTQAKDEYQGGDVQDALEADDDIHVKAASGATIAEEAPGVYKDIDDVVDVSAGLGVGDPVVRTYPVCNVKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP038631
EMBL· GenBank· DDBJ
QCC45214.1
EMBL· GenBank· DDBJ
Genomic DNA
VRYN01000007
EMBL· GenBank· DDBJ
TYO75114.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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