A0A498LH34 · A0A498LH34_LABRO
- Protein2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids528 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.
Catalytic activity
- L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H+ + S-methyl-5'-thioadenosine
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Pathway
Protein modification; peptidyl-diphthamide biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-(3-amino-3-carboxypropyl)histidine synthase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | protein histidyl modification to diphthamide |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Labeoninae > Labeonini > Labeo
Accessions
- Primary accessionA0A498LH34
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length528
- Mass (Da)59,069
- Last updated2019-06-05 v1
- Checksum66BC98E2F571AFB7
Keywords
- Technical term