A0A498LH34 · A0A498LH34_LABRO

Function

function

Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Protein modification; peptidyl-diphthamide biosynthesis.

GO annotations

AspectTerm
Molecular Function2-(3-amino-3-carboxypropyl)histidine synthase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological Processprotein histidyl modification to diphthamide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
  • EC number

Gene names

    • ORF names
      ROHU_011849

Organism names

  • Taxonomic identifier
  • Strain
    • DASCIFA01
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Labeoninae > Labeonini > Labeo

Accessions

  • Primary accession
    A0A498LH34

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    528
  • Mass (Da)
    59,069
  • Last updated
    2019-06-05 v1
  • Checksum
    66BC98E2F571AFB7
MASTVDLLTSVLCSMSNACFTPRALVWGKMAAPTSEIEVVTAKKPNVRGPRRVANQIPDEILKDPELSEAIKALPANYNFEIHKTIWRVRQAKAKRVALQLPEGLQMFACVIADIIESVLLRPVDEDGDRYLLALFIRQCCCGPRPTAPVGEMSELVWRKDPGMGPTIPIPDSHCTAELFTEADTLVMGDVTYGACCVDDFTARALGADFMVHYGHSCLKNNRREGNEAMETVTESMTLIDNSCNCIPIDSTEGIKMLYVFVDIQIDTAHFLDTLRFNFPRGHSLALVSTIQFVAALQAASAELKPDYEVLVPQCRPLSPGEILGCTSPRLEKQVNAIIYLGDGRFHLESIMIANPDIPAYRYDPYNKVFSREYYDHEAMRATRLQAIESARSAQRWGLILGTLGRQGNPKILEHLESRLESLGRSFTRVLLSEIFPGKLELLADVDAWVQIACPRLSIDWGTAFSKPLLSPYEAAVALQQVEWQEVYPMDFYSNQSLGAWTPNHQDNQPKRPSRKPMQFLKTCMAHQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QBIY01013344
EMBL· GenBank· DDBJ
RXN07619.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp