A0A496CB02 · A0A496CB02_9BACT

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site975-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site1015-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site123-1315-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site127orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Biological Process'de novo' UMP biosynthetic process
Biological Processpyrimidine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • ORF names
      DWW91_26220

Organism names

  • Taxonomic identifier
  • Strain
    • AF17-3
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Tannerellaceae > Parabacteroides

Accessions

  • Primary accession
    A0A496CB02

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain57-154Phosphoribosyltransferase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    23,227
  • Last updated
    2019-06-05 v1
  • Checksum
    B98AB1733F57B5D9
MKTLERLVAEKLLKIKAVKLQPANPFTWASGWRSPIYNDNRKTLSYPAVRSFIKLELARVISEKYENADAIAGVATGAIAQGALVADLLGLPFVYIRATPKDHGLENLIEGELKPGSKVVIIEDLVSTGGSSLKAVQAVRNFGCDVVGMVAIFTYGFPVAVEAFKDAKVQLTTLSNYDAVLEEAVRTDYIDESEISILQEWRKDPSNWNPGV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QTMM01000027
EMBL· GenBank· DDBJ
RKU62443.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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