A0A495KGS2 · A0A495KGS2_ENTAS

  • Protein
    Probable endonuclease 4
  • Gene
    nfo
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

128520406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site69Zn2+ 1 (UniProtKB | ChEBI)
Binding site109Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 2 (UniProtKB | ChEBI)
Binding site179Zn2+ 2 (UniProtKB | ChEBI)
Binding site182Zn2+ 3 (UniProtKB | ChEBI)
Binding site216Zn2+ 2 (UniProtKB | ChEBI)
Binding site229Zn2+ 3 (UniProtKB | ChEBI)
Binding site231Zn2+ 3 (UniProtKB | ChEBI)
Binding site261Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • ORF names
      JGT27_17815

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 170C2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex

Accessions

  • Primary accession
    A0A495KGS2

Proteomes

Family & Domains

Sequence similarities

Belongs to the AP endonuclease 2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    31,390
  • Last updated
    2019-06-05 v1
  • MD5 Checksum
    4D699C7035306FDE317B2DDF5BF85E5E
MKYVGAHVSAAGGLANAAIRAAEIEATAFALFTKNQRQWRAAALTAEVIDDFKAACEKYHYGPGQILPHDSYLINLGHPVEEALEKSREAFLDEVQRCEQLGLTLLNFHPGSHLMQIDEDACLARIAESINITLDKTKGVTAVIENTAGQGSNLGFRFEHLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLRTTEATKNTFDEFERIVGFKYLRGMHLNDAKSAFGSRVDRHHSLGEGNIGHDAFRFIMQDARFDGIPMVLETINPDIWAEEIAWLKAQQTAEQAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAELXN010000065
EMBL· GenBank· DDBJ
MBJ6597552.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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