A0A493TTW5 · A0A493TTW5_ANAPP

Function

Catalytic activity

  • 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+
    This reaction proceeds in the forward direction.
  • 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+
    This reaction proceeds in the forward direction.
  • 3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxocholesterol + NADPH + H+ = 7beta-hydroxycholesterol + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxolithocholate + NADPH + H+ = ursodeoxycholate + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxopregnenolone + NADPH + H+ = 7beta-hydroxypregnenolone + NADP+
    This reaction proceeds in the forward direction.
  • taurochenodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • tauroursodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.1.1.201 (UniProtKB | ENZYME | Rhea)
  • an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
    This reaction proceeds in the forward
    and the backward
    directions.
    EC:1.1.1.146 (UniProtKB | ENZYME | Rhea)
  • chenodeoxycholate + NADP+ = 7-oxolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • corticosterone + NADP+ = 11-dehydrocorticosterone + NADPH + H+
    This reaction proceeds in the forward
    and the backward
    directions.
  • glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Function11-beta-hydroxysteroid dehydrogenase (NADP+) activity
Molecular Functionsteroid binding
Biological Processsteroid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    11-beta-hydroxysteroid dehydrogenase 1
  • EC number
  • Alternative names
    • 7-oxosteroid reductase
    • Corticosteroid 11-beta-dehydrogenase isozyme 1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Anseriformes > Anatidae > Anatinae > Anas

Accessions

  • Primary accession
    A0A493TTW5

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type II membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-25
ChainPRO_501980000826-23111-beta-hydroxysteroid dehydrogenase 1

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region211-231Disordered

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    231
  • Mass (Da)
    24,634
  • Last updated
    2019-06-05 v1
  • Checksum
    9E26F3CD26457334
MGLLLKVILPLMGLGLAMLAATSKGALLPGGLDMLILNHIGHSYFNYFDGDVDHIRKLLETNFLSYVAMTVTALPMLKESEGNIVVVSSVAGKAPGPFAAPYSATKFALDGFFSSLRHEFIIENVNVSITLCILGYIDTGKLNATGARGLRRVAPSPKEECALEIIRSGALRQHELHYPPGIVNGMLLLRGLAPGFLDTLIRSNIVVENVQRAPPPHGTRVPPAGSPGSGR

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A493SV41A0A493SV41_ANAPP312
U3IVN3U3IVN3_ANAPP240
U3IWF6U3IWF6_ANAPP309
A0A493TAL2A0A493TAL2_ANAPP306
A0A493TLE5A0A493TLE5_ANAPP292
A0A493SY82A0A493SY82_ANAPP288
A0A493TJR1A0A493TJR1_ANAPP270
A0A493STK5A0A493STK5_ANAPP294

Keywords

Genome annotation databases

Similar Proteins

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