A0A493TTW5 · A0A493TTW5_ANAPP
- Protein11-beta-hydroxysteroid dehydrogenase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids231 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+This reaction proceeds in the forward direction.
- 7-oxocholesterol + NADPH + H+ = 7beta-hydroxycholesterol + NADP+This reaction proceeds in the forward direction.
- 7-oxolithocholate + NADPH + H+ = ursodeoxycholate + NADP+This reaction proceeds in the forward direction.
- 7-oxopregnenolone + NADPH + H+ = 7beta-hydroxypregnenolone + NADP+This reaction proceeds in the forward direction.
- taurochenodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- tauroursodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- chenodeoxycholate + NADP+ = 7-oxolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- corticosterone + NADP+ = 11-dehydrocorticosterone + NADPH + H+This reaction proceeds in the forward and the backward directions.
- glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+This reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity | |
Molecular Function | steroid binding | |
Biological Process | steroid catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name11-beta-hydroxysteroid dehydrogenase 1
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Anseriformes > Anatidae > Anatinae > Anas
Accessions
- Primary accessionA0A493TTW5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-25 | ||||
Chain | PRO_5019800008 | 26-231 | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length231
- Mass (Da)24,634
- Last updated2019-06-05 v1
- Checksum9E26F3CD26457334
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A493SV41 | A0A493SV41_ANAPP | 312 | |||
U3IVN3 | U3IVN3_ANAPP | 240 | |||
U3IWF6 | U3IWF6_ANAPP | 309 | |||
A0A493TAL2 | A0A493TAL2_ANAPP | 306 | |||
A0A493TLE5 | A0A493TLE5_ANAPP | 292 | |||
A0A493SY82 | A0A493SY82_ANAPP | 288 | |||
A0A493TJR1 | A0A493TJR1_ANAPP | 270 | |||
A0A493STK5 | A0A493STK5_ANAPP | 294 |
Keywords
- Technical term