A0A484DPC9 · A0A484DPC9_PERFV
- ProteinAlpha-ketoglutarate-dependent dioxygenase FTO
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids660 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 2-oxoglutarate + N6-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate
- 2-oxoglutarate + a 5'-end (N7-methyl 5'-triphosphoguanosine)-(N6,2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate
- 2-oxoglutarate + a 5'-end (N7-methyl 5'-triphosphoguanosine)-(N6,2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate
- 2-oxoglutarate + an N1-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Molecular Function | broad specificity oxidative DNA demethylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidative RNA demethylase activity | |
Biological Process | DNA alkylation repair | |
Biological Process | regulation of multicellular organism growth | |
Biological Process | RNA repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-ketoglutarate-dependent dioxygenase FTO
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca
Accessions
- Primary accessionA0A484DPC9
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-42 | Disordered | ||||
Sequence: MKKPLVRVLQQPASPRMKARQCKHKSRNMKRSGDSEGEKRRK | ||||||
Compositional bias | 28-42 | Basic and acidic residues | ||||
Sequence: NMKRSGDSEGEKRRK | ||||||
Domain | 62-483 | Alpha-ketoglutarate-dependent dioxygenase FTO catalytic | ||||
Sequence: DRGYQQLWDSSYSGLVLRRSCSLPAELHGRVQAALLTLRRKGCLLRDLVRIRDRDVFTAVSRALLGEPGHTYRYLDTRLFAIPWHSEDTDVKGQNCCDPDFRAACRALWELNTFFCSDVSQLKEGDRLTQCAKREAEAKQGEEGDTGSKHSEDSKNSEGGDSESRQSEEGDTESKHSEEWDIESKHSEEGCSGSKQEGEWETESKHSSEEGESSQVKPSEAAVAAGSEHSEGKFPGWAPKAISGTETKPVGLGAQEKPVAQLKHSLSGYHIEDTEEQASGQGCSQPSPPQVYTGPVKFNVTLLNYMDPAATGQLKEEPYYGMGKMAVGWHHDENLISHSPVAVYSHSCHNDKGESSEGGSGEMACWRIGLKVAWDIHTPGLMLPLESGDCYYMRDDLNSTHQHCVLAGETTRFSSTHRVAEC | ||||||
Compositional bias | 194-274 | Basic and acidic residues | ||||
Sequence: KREAEAKQGEEGDTGSKHSEDSKNSEGGDSESRQSEEGDTESKHSEEWDIESKHSEEGCSGSKQEGEWETESKHSSEEGES | ||||||
Region | 194-311 | Disordered | ||||
Sequence: KREAEAKQGEEGDTGSKHSEDSKNSEGGDSESRQSEEGDTESKHSEEWDIESKHSEEGCSGSKQEGEWETESKHSSEEGESSQVKPSEAAVAAGSEHSEGKFPGWAPKAISGTETKPV |
Sequence similarities
Belongs to the fto family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length660
- Mass (Da)74,401
- Last updated2019-06-05 v1
- Checksum801213271A26566B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 28-42 | Basic and acidic residues | ||||
Sequence: NMKRSGDSEGEKRRK | ||||||
Compositional bias | 194-274 | Basic and acidic residues | ||||
Sequence: KREAEAKQGEEGDTGSKHSEDSKNSEGGDSESRQSEEGDTESKHSEEWDIESKHSEEGCSGSKQEGEWETESKHSSEEGES |
Keywords
- Technical term