A0A484DFX2 · A0A484DFX2_PERFV

Function

function

Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.8.22 (UniProtKB | ENZYME | Rhea)
  • 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.8.2 (UniProtKB | ENZYME | Rhea)
  • 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.8.2 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.8.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear membrane
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Choline/ethanolaminephosphotransferase 1
  • EC number
  • Alternative names
    • 1-alkenyl-2-acylglycerol choline phosphotransferase

Gene names

    • ORF names
      EPR50_G00035270

Organism names

  • Taxonomic identifier
  • Strain
    • YP-PL-M2
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca

Accessions

  • Primary accession
    A0A484DFX2

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Nucleus membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane148-169Helical
Transmembrane175-193Helical
Transmembrane242-262Helical
Transmembrane277-297Helical
Transmembrane309-327Helical
Transmembrane347-365Helical
Transmembrane377-397Helical
Transmembrane423-445Helical
Transmembrane466-491Helical
Transmembrane518-538Helical
Transmembrane558-576Helical
Transmembrane582-608Helical
Transmembrane620-646Helical
Transmembrane666-691Helical

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region18-77Disordered
Compositional bias45-63Polar residues

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    732
  • Mass (Da)
    81,276
  • Last updated
    2019-06-05 v1
  • Checksum
    93A471D6A5549366
MFTSFFQCLERALTAPRTAHGSRPLTGQIQRQDSGRGGAKAIGDQTSRQKGSMSATGQQQAGGLRSRRGLGRDKDPGQGMGMEAACWLAPGVLRRLIELPSPPLSRHQLKRLEEHRYSSAGRSLLEPLMQRYWEWLVGRVPSWIAPNLITIIGLATNVFTTLVLIYYCPTATEQAPLWAYLLCAVGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTSIAVQMGTNPDWMFFCCFAGMFMFYCAHWQTYVSGTLRFGIIDVTEVQLFIIIMYLLAAVGGSALWQSMIPILNIQMKMIPAICTFLGAIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPVLHIGSVIILAMMIYKKSAVQLFEKHPCLYILAFGFVSAKITNKLVVAHMTKSEMHLHDLAFLGPGLLFLDQYFNSFIDEYLVLWIALIISFFDLQEDCGRWRTRITTHSEETMWWFQQGLCFLPAALVVWTAASFVFAYITAVSLRHVDPLVPYISDTGTMAPERCVFGIMLDVSAFLGIATVYVRYKQVEALTGEGEFKLNRLNRFGLLLGLISSFGMCVVANFQKTTLFSMHLVGAVLTFGVGALYIVVQTLLSLHMQPHVHSRTIYLVRLSLGLWTMSSIISMFVSSVIMYSSLPGVDVPHKLHWTPGETGYTAHIISTVSEWSLAFSFISFFLTYIRDFQKIHLRAEADVQSSHLYDNWPHDGVAASESSPLLAGGT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias45-63Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SCKG01000004
EMBL· GenBank· DDBJ
TDH14336.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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