A0A484DFX2 · A0A484DFX2_PERFV
- ProteinCholine/ethanolaminephosphotransferase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids732 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
Catalytic activity
- 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Pathway
Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nuclear membrane | |
Molecular Function | phosphotransferase activity, for other substituted phosphate groups | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCholine/ethanolaminephosphotransferase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca
Accessions
- Primary accessionA0A484DFX2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Nucleus membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 148-169 | Helical | ||||
Sequence: LITIIGLATNVFTTLVLIYYCP | ||||||
Transmembrane | 175-193 | Helical | ||||
Sequence: APLWAYLLCAVGLFIYQSL | ||||||
Transmembrane | 242-262 | Helical | ||||
Sequence: WMFFCCFAGMFMFYCAHWQTY | ||||||
Transmembrane | 277-297 | Helical | ||||
Sequence: VQLFIIIMYLLAAVGGSALWQ | ||||||
Transmembrane | 309-327 | Helical | ||||
Sequence: MIPAICTFLGAIFSCTNYF | ||||||
Transmembrane | 347-365 | Helical | ||||
Sequence: VLSPVLHIGSVIILAMMIY | ||||||
Transmembrane | 377-397 | Helical | ||||
Sequence: PCLYILAFGFVSAKITNKLVV | ||||||
Transmembrane | 423-445 | Helical | ||||
Sequence: YFNSFIDEYLVLWIALIISFFDL | ||||||
Transmembrane | 466-491 | Helical | ||||
Sequence: WFQQGLCFLPAALVVWTAASFVFAYI | ||||||
Transmembrane | 518-538 | Helical | ||||
Sequence: VFGIMLDVSAFLGIATVYVRY | ||||||
Transmembrane | 558-576 | Helical | ||||
Sequence: FGLLLGLISSFGMCVVANF | ||||||
Transmembrane | 582-608 | Helical | ||||
Sequence: FSMHLVGAVLTFGVGALYIVVQTLLSL | ||||||
Transmembrane | 620-646 | Helical | ||||
Sequence: YLVRLSLGLWTMSSIISMFVSSVIMYS | ||||||
Transmembrane | 666-691 | Helical | ||||
Sequence: YTAHIISTVSEWSLAFSFISFFLTYI |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 18-77 | Disordered | ||||
Sequence: TAHGSRPLTGQIQRQDSGRGGAKAIGDQTSRQKGSMSATGQQQAGGLRSRRGLGRDKDPG | ||||||
Compositional bias | 45-63 | Polar residues | ||||
Sequence: QTSRQKGSMSATGQQQAGG |
Sequence similarities
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length732
- Mass (Da)81,276
- Last updated2019-06-05 v1
- Checksum93A471D6A5549366
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 45-63 | Polar residues | ||||
Sequence: QTSRQKGSMSATGQQQAGG |
Keywords
- Technical term