A0A484DEM6 · A0A484DEM6_PERFV
- Proteinreceptor protein-tyrosine kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1375 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 1071-1079 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1097 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1144-1147 | ATP (UniProtKB | ChEBI) | |||
Active site | 1191 | Proton acceptor | |||
Binding site | 1195 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basal plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | hepatocyte growth factor receptor activity | |
Biological Process | axon guidance | |
Biological Process | cell migration | |
Biological Process | liver development | |
Biological Process | pancreas development | |
Biological Process | positive regulation of kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca
Accessions
- Primary accessionA0A484DEM6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 943-967 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5019727684 | 22-1375 | receptor protein-tyrosine kinase | ||
Disulfide bond | 98↔101 | ||||
Disulfide bond | 133↔141 | ||||
Disulfide bond | 167↔170 | ||||
Disulfide bond | 293↔360 | ||||
Disulfide bond | 378↔399 | ||||
Disulfide bond | 512↔530 | ||||
Disulfide bond | 518↔552 | ||||
Disulfide bond | 521↔537 | ||||
Disulfide bond | 533↔543 | ||||
Modified residue | 1221 | Phosphotyrosine; by autocatalysis | |||
Modified residue | 1222 | Phosphotyrosine; by autocatalysis | |||
Modified residue | 1336 | Phosphotyrosine; by autocatalysis | |||
Modified residue | 1343 | Phosphotyrosine; by autocatalysis | |||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 24-507 | Sema | |||
Domain | 1065-1328 | Protein kinase | |||
Region | 1350-1375 | Disordered | |||
Sequence similarities
Belongs to the plexin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,375
- Mass (Da)153,106
- Last updated2019-06-05 v1
- Checksum6B6DCBDF291C521A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
SCKG01000004 EMBL· GenBank· DDBJ | TDH13909.1 EMBL· GenBank· DDBJ | Genomic DNA |