A0A484CYU4 · A0A484CYU4_PERFV
- ProteinMast/stem cell growth factor receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids971 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 560 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 588-595 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GSGAFGKV | ||||||
Binding site | 615 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 663-669 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EYCCFGD | ||||||
Active site | 783 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 787 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 788 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 801 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Site | 913 | Important for interaction with phosphotyrosine-binding proteins | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | cytokine binding | |
Molecular Function | growth factor binding | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | B cell differentiation | |
Biological Process | Fc receptor signaling pathway | |
Biological Process | hematopoietic progenitor cell differentiation | |
Biological Process | Kit signaling pathway | |
Biological Process | positive regulation of cell migration | |
Biological Process | positive regulation of MAP kinase activity | |
Biological Process | positive regulation of receptor signaling pathway via JAK-STAT | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMast/stem cell growth factor receptor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca
Accessions
- Primary accessionA0A484CYU4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 513-537 | Helical | ||||
Sequence: LFTPLLIGSVSAAGILCLVLIMLFY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MITMEYHWILLAVFLQLTFHPGST | ||||||
Chain | PRO_5019622009 | 25-971 | Mast/stem cell growth factor receptor | |||
Sequence: KPTITPVGPHLVVLLNAPFELLCQGEKEMQWQREDRPKVRGEKKSAGMSALHIPRAQPVHMGRYICLEESSKEQLSIYVYVKDPDNPFRKSMVFNILTRVGDNASISCLATDPSLDNLRLETCSGRALASGLQFTASLEQGILIHNTQKAYEGCYVCTGRLREEYVQSHDYSLTVRPVPVAPPVIEMATKRVILTRNESLSLTCNTSNVNGEITLKWVTPPGSQPAKVDGASRILSEDFTHVRSATLHNAAVGHQDAGRYQCEAQNERGTSSRSVWLDVYEKGFINLTPTINETIQVRSGESLPLNVDMEAYPKPHTFSWSFMGRELRNTSDHVITTHSHEYRYSSELRLVRLKMSESGVYTFQASNGDASVNHTFTIFVISKPEIVSREGPVDGQVRCVAEGFPAPQITWYYCEQPYARCSQQVNATQEERNVITVTLFSPLFGKTEVESRVNVSRGRFSTLECVATVEGEQAYTLFSISERTVPHDLFTPLLIGSVSAAGILCLVLIMLFYKYMQKPKYQIQWKVIEGIHGNNYVYIDPTQLPYDHQWEFPRNNLRFGKTLGSGAFGKVVEATAYGLSEADSVMTVAVKMLKTSAHATEKEALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRESFICYKLEEDCYYRNVMPQRDAAGGNFNGYMSMRPSAAGNLPFSSSSEKRRSLRKGDSYVEADAESEMFDEDGLSLDTEDLLSFSHQVAKGMEFLAAKNCIHRDLAARNILLTQGRVAKICDFGLARDINTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGNSPYPGMPVDAKFYKLIKEGYRMDAPEFATSEMYQIMRKVVERIEQQLSDATKHIYLNFSSKLPVTSRAREEPGPQGAPFHRVNSASNDSGPTQPLLLQHEVFLEGTTLRAQRV |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 206-302 | Ig-like | ||||
Sequence: PPVIEMATKRVILTRNESLSLTCNTSNVNGEITLKWVTPPGSQPAKVDGASRILSEDFTHVRSATLHNAAVGHQDAGRYQCEAQNERGTSSRSVWLD | ||||||
Domain | 313-403 | Ig-like | ||||
Sequence: PTINETIQVRSGESLPLNVDMEAYPKPHTFSWSFMGRELRNTSDHVITTHSHEYRYSSELRLVRLKMSESGVYTFQASNGDASVNHTFTIF | ||||||
Domain | 581-914 | Protein kinase | ||||
Sequence: LRFGKTLGSGAFGKVVEATAYGLSEADSVMTVAVKMLKTSAHATEKEALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRESFICYKLEEDCYYRNVMPQRDAAGGNFNGYMSMRPSAAGNLPFSSSSEKRRSLRKGDSYVEADAESEMFDEDGLSLDTEDLLSFSHQVAKGMEFLAAKNCIHRDLAARNILLTQGRVAKICDFGLARDINTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGNSPYPGMPVDAKFYKLIKEGYRMDAPEFATSEMYQIMRKVVERIEQQLSDATKHIYL | ||||||
Region | 923-951 | Disordered | ||||
Sequence: TSRAREEPGPQGAPFHRVNSASNDSGPTQ |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length971
- Mass (Da)109,095
- Last updated2019-06-05 v1
- ChecksumC3C56722BCE259CD
Keywords
- Technical term