A0A484CVY3 · A0A484CVY3_PERFV
- ProteinPeroxisomal bifunctional enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids725 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoAThis reaction proceeds in the forward direction.
- (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3E)-decenoyl-CoA = (2E)-decenoyl-CoAThis reaction proceeds in the forward direction.
- (3E)-hexenoyl-CoA = (2E)-hexenoyl-CoAThis reaction proceeds in the forward direction.
- (3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoAThis reaction proceeds in the backward direction.
- (3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoAThis reaction proceeds in the backward direction.
- (3S)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3S)-hydroxyhexadecanedioyl-CoA + NAD+ = 3-oxohexadecanedioyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA + NAD+ = 3-oxohexadecanoyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid beta-oxidation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | enoyl-CoA hydratase activity | |
Molecular Function | NAD+ binding | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeroxisomal bifunctional enzyme
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca
Accessions
- Primary accessionA0A484CVY3
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 304-477 | 3-hydroxyacyl-CoA dehydrogenase NAD binding | ||||
Sequence: KAAVIGLGTMGRGITVALAQTGLSVVAVETQEKQLMEAKQAVSGMLERGAKRHGVAPMLDRISYSQNIQAVAEVDLVIEAVFEDMALKTEVFQQLSAVCKPGTLLCTNTSALDVDKLASEMPNPELVVGMHFFAPAHVMKLLEVVYGPRSSPQAVATAMQLGKKMGKVSVAVGN | ||||||
Domain | 480-584 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: GFVGNRMLMPYLQQAFFLLEEGATPELVDRALEEFGFPMGVFRMSDLSGLDIGWRVRKRDELVEPDMASGQSARIRQGSRYSPLGDLLCEQGRFGQKTGQGWYRY | ||||||
Domain | 621-706 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: VLERCLYALINEGFRILEDGIAAGPEDIDVIYVFGYGWPRHRGGPMFYASMVGLAKILERLEHYQQAHPDVPYLQPSSLLRRLVAS |
Sequence similarities
Belongs to the enoyl-CoA hydratase/isomerase family.
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length725
- Mass (Da)78,815
- Last updated2019-06-05 v1
- Checksum220BA8A234B9068F
Keywords
- Technical term