A0A484CR60 · A0A484CR60_PERFV
- ProteinHedgehog protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids413 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Protein hedgehog N-product
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.
Protein hedgehog
The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
Catalytic activity
- cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 88 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 89 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 89 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 94 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 124 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 125 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 125 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 128 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 130 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 139 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 146 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 181 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 196-197 | Cleavage; by autolysis | ||||
Sequence: GC | ||||||
Site | 242 | Involved in cholesterol transfer | ||||
Sequence: D | ||||||
Site | 266 | Involved in auto-cleavage | ||||
Sequence: T | ||||||
Site | 269 | Essential for auto-cleavage | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | extracellular space | |
Cellular Component | Golgi membrane | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | patched binding | |
Molecular Function | peptidase activity | |
Molecular Function | transferase activity | |
Biological Process | animal organ development | |
Biological Process | cell development | |
Biological Process | cell fate specification | |
Biological Process | cell-cell signaling | |
Biological Process | central nervous system development | |
Biological Process | intein-mediated protein splicing | |
Biological Process | neuron differentiation | |
Biological Process | pattern specification process | |
Biological Process | protein autoprocessing | |
Biological Process | regulation of cell population proliferation | |
Biological Process | regulation of developmental process | |
Biological Process | regulation of gene expression | |
Biological Process | smoothened signaling pathway | |
Biological Process | tissue development | |
Biological Process | tube development |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHedgehog protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca
Accessions
- Primary accessionA0A484CR60
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Lipid-anchor
Sonic hedgehog protein
Protein hedgehog N-product
Cell membrane ; Lipid-anchor
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MVLMRVMLSATLFLLLTSVGSG | ||||||
Chain | PRO_5019861998 | 23-413 | Hedgehog protein | |||
Sequence: CGPGRGHGKRRHPKKLTPLALKQFIPNVAEKTLGASGKCEGKITRNSDRFKDLTPSYNPDIIFKDEENTNADRLMTQRCKDKLNSLAISVMNQWPGVKLRVTEGWDEDGHHSDESLHYEGRAVDITTSDRDKSKYGMLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSSIVILSDGRTKPLKELQVGDKVLATDQQGNLVPSDFLMFMDQDEQIMREFHVLETEEPRCRLTLTAAHLVFVMSNNNGTNSSDIRAVFSSNVKLGQWLLVVGNDRPDHLIPARVTRIHVEKYRGSYAPVTSHGTIIVDWVLASCYAVVEDHDLAHWVFVPVRLWRSFLSLVGMVKELSSVYQTEGIHWYPELLYHVGSWVLDSSSFHPQTGL |
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 195-303 | Hint | ||||
Sequence: GGCFPGSSIVILSDGRTKPLKELQVGDKVLATDQQGNLVPSDFLMFMDQDEQIMREFHVLETEEPRCRLTLTAAHLVFVMSNNNGTNSSDIRAVFSSNVKLGQWLLVVG | ||||||
Domain | 307-351 | Hint | ||||
Sequence: PDHLIPARVTRIHVEKYRGSYAPVTSHGTIIVDWVLASCYAVVED |
Sequence similarities
Belongs to the hedgehog family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length413
- Mass (Da)46,243
- Last updated2019-06-05 v1
- Checksum48486956645B823B
Keywords
- Technical term