A0A484CR60 · A0A484CR60_PERFV

Function

function

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site88Ca2+ 1 (UniProtKB | ChEBI)
Binding site89Ca2+ 1 (UniProtKB | ChEBI)
Binding site89Ca2+ 2 (UniProtKB | ChEBI)
Binding site94Ca2+ 1 (UniProtKB | ChEBI)
Binding site124Ca2+ 1 (UniProtKB | ChEBI)
Binding site125Ca2+ 2 (UniProtKB | ChEBI)
Binding site125Ca2+ 1 (UniProtKB | ChEBI)
Binding site128Ca2+ 2 (UniProtKB | ChEBI)
Binding site130Ca2+ 2 (UniProtKB | ChEBI)
Binding site139Zn2+ (UniProtKB | ChEBI)
Binding site146Zn2+ (UniProtKB | ChEBI)
Binding site181Zn2+ (UniProtKB | ChEBI)
Site196-197Cleavage; by autolysis
Site242Involved in cholesterol transfer
Site266Involved in auto-cleavage
Site269Essential for auto-cleavage

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionpatched binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Biological Processanimal organ development
Biological Processcell development
Biological Processcell fate specification
Biological Processcell-cell signaling
Biological Processcentral nervous system development
Biological Processintein-mediated protein splicing
Biological Processneuron differentiation
Biological Processpattern specification process
Biological Processprotein autoprocessing
Biological Processregulation of cell population proliferation
Biological Processregulation of developmental process
Biological Processregulation of gene expression
Biological Processsmoothened signaling pathway
Biological Processtissue development
Biological Processtube development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Gene names

    • ORF names
      EPR50_G00131610

Organism names

  • Taxonomic identifier
  • Strain
    • YP-PL-M2
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca

Accessions

  • Primary accession
    A0A484CR60

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
Membrane
; Lipid-anchor

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_501986199823-413Hedgehog protein

Keywords

Interaction

Subunit

Multimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain195-303Hint
Domain307-351Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    413
  • Mass (Da)
    46,243
  • Last updated
    2019-06-05 v1
  • Checksum
    48486956645B823B
MVLMRVMLSATLFLLLTSVGSGCGPGRGHGKRRHPKKLTPLALKQFIPNVAEKTLGASGKCEGKITRNSDRFKDLTPSYNPDIIFKDEENTNADRLMTQRCKDKLNSLAISVMNQWPGVKLRVTEGWDEDGHHSDESLHYEGRAVDITTSDRDKSKYGMLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSSIVILSDGRTKPLKELQVGDKVLATDQQGNLVPSDFLMFMDQDEQIMREFHVLETEEPRCRLTLTAAHLVFVMSNNNGTNSSDIRAVFSSNVKLGQWLLVVGNDRPDHLIPARVTRIHVEKYRGSYAPVTSHGTIIVDWVLASCYAVVEDHDLAHWVFVPVRLWRSFLSLVGMVKELSSVYQTEGIHWYPELLYHVGSWVLDSSSFHPQTGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SCKG01000012
EMBL· GenBank· DDBJ
TDH06231.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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