A0A484C046 · A0A484C046_PERFV
- ProteinSerine/threonine-protein kinase receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids506 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- ATP + L-seryl-[receptor-protein] = ADP + H+ + O-phospho-L-seryl-[receptor-protein]
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | activin receptor complex | |
Cellular Component | bicellular tight junction | |
Cellular Component | cell surface | |
Cellular Component | membrane raft | |
Molecular Function | activin binding | |
Molecular Function | activin receptor activity, type I | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | SMAD binding | |
Molecular Function | transforming growth factor beta receptor activity, type I | |
Biological Process | apoptotic process | |
Biological Process | cell differentiation | |
Biological Process | heart development | |
Biological Process | nervous system development | |
Biological Process | transforming growth factor beta receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase receptor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Percinae > Perca
Accessions
- Primary accessionA0A484C046
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 117-140 | Helical | ||||
Sequence: VALAAVIAGPVCVFCLLLVLAFYV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MDAIPCLLFVLLFGTLIQEHTA | ||||||
Chain | PRO_5019838605 | 23-506 | Serine/threonine-protein kinase receptor | |||
Sequence: LQCYCDRCSANSSCTTDGVCFVAIRMSGNQQTTDQRQCVHENELIPRDRPFICAPSVKQDKGIYPFCCTTDNCNEKPEWGTIPVPTVKTPPLGPVALAAVIAGPVCVFCLLLVLAFYVCHSHRGLGAGGAGAHHHHHRVPNEEDPSMDHPFITVGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIILQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIASRCSMGGIHEDYQLPYYDLVQSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANSAARLTALRIKKTLSQLSQQEGIKM |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 178-207 | GS | ||||
Sequence: TTLKDLIYDMTTSGSGSGLPLLVQRTIART | ||||||
Domain | 208-498 | Protein kinase | ||||
Sequence: IILQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIASRCSMGGIHEDYQLPYYDLVQSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANSAARLTALRIKKTLSQL |
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length506
- Mass (Da)56,686
- Last updated2019-06-05 v1
- Checksum7F0FF96DE1AE5284
Keywords
- Technical term