A0A482LU84 · A0A482LU84_9REOV

  • Protein
    Intermediate capsid protein VP6
  • Gene
    VP6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.

Miscellaneous

The VP6 trimer contains a zinc ion located at the center of the molecule. The zinc ion is not essential for either trimerization or transcription activity of the DLP. Zinc-depleted VP6 has an increased sensitivity to proteases.

Features

Showing features for binding site.

139750100150200250300350
TypeIDPosition(s)Description
Binding site153Zn2+ (UniProtKB | ChEBI); ligand shared between all trimeric partners
Binding site266Ca2+ (UniProtKB | ChEBI)
Binding site286Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentviral envelope
Cellular Componentviral intermediate capsid
Molecular Functionhost cell surface receptor binding
Molecular Functionmetal ion binding
Molecular Functionstructural molecule activity
Biological Processfusion of virus membrane with host plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Intermediate capsid protein VP6

Gene names

    • Name
      VP6

Organism names

  • Taxonomic identifier
  • Organism
    Rotavirus A
  • Strain
    • RVA/Pig/China/SC11/2017/G9P[23]
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Duplornaviricota > Resentoviricetes > Reovirales > Sedoreoviridae > Rotavirus

Accessions

  • Primary accession
    A0A482LU84

Subcellular Location

Virion
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

Keywords

PTM/Processing

Post-translational modification

Sumoylated with SUMO1 and SUMO2. Sumoylation of viral proteins seems to have a positive role on viral replication.
The N-terminus is blocked.

Keywords

Interaction

Subunit

Homotrimer. Interacts with the inner capsid protein VP2. Interacts with the outer capsid glycoprotein VP7. Interacts with the outer capsid protein VP5*.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region62-73Interaction with the inner capsid protein VP2

Sequence similarities

Belongs to the rotavirus VP6 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    397
  • Mass (Da)
    44,845
  • Last updated
    2019-06-05 v1
  • Checksum
    039859946E145877
MDVLYSLSRTLKDARDKIVEGTLYSNVSDLIQQFNQMLVTMNGNDFQTGGIGNLPIRNWTFNFGLLGTTLLNLDANYVENARTTIEYFIDFIDNVCMDEMARESQRNGLAPQSEALRKLSGVRFKRINFDNSSDYIENWNLQNRRQRTGFVFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANIQQFEHIVPLRRALTTATITLLPDAERFSFPRVINSADGTTTWFFNPVIFRPSNVEIEFLLNGQVINTYQARFGTIVARNFDTIRLSFQLVRPPNMTPAVTNILPQAPPFIFHATVGITLRIDSAVCESVLADATETLLANVTAVRQEYAIPVGPVFPPGMNWTELITNYLPSREDNLQRVFTVASIRSMLIK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH624177
EMBL· GenBank· DDBJ
QBQ58262.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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