A0A482LU84 · A0A482LU84_9REOV
- ProteinIntermediate capsid protein VP6
- GeneVP6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids397 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.
Miscellaneous
The VP6 trimer contains a zinc ion located at the center of the molecule. The zinc ion is not essential for either trimerization or transcription activity of the DLP. Zinc-depleted VP6 has an increased sensitivity to proteases.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | viral envelope | |
Cellular Component | viral intermediate capsid | |
Molecular Function | host cell surface receptor binding | |
Molecular Function | metal ion binding | |
Molecular Function | structural molecule activity | |
Biological Process | fusion of virus membrane with host plasma membrane |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameIntermediate capsid protein VP6
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Duplornaviricota > Resentoviricetes > Reovirales > Sedoreoviridae > Rotavirus
Accessions
- Primary accessionA0A482LU84
Subcellular Location
UniProt Annotation
GO Annotation
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Keywords
- Cellular component
PTM/Processing
Post-translational modification
Sumoylated with SUMO1 and SUMO2. Sumoylation of viral proteins seems to have a positive role on viral replication.
The N-terminus is blocked.
Keywords
- PTM
Interaction
Subunit
Homotrimer. Interacts with the inner capsid protein VP2. Interacts with the outer capsid glycoprotein VP7. Interacts with the outer capsid protein VP5*.
Structure
Sequence
- Sequence statusComplete
- Length397
- Mass (Da)44,845
- Last updated2019-06-05 v1
- Checksum039859946E145877