Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A481S5Z9 · A0A481S5Z9_HV1

Function

Catalytic activity

  • 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
    EC:3.1.13.2 (UniProtKB | ENZYME | Rhea)
  • Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
    EC:3.1.26.13 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding.

110031002003004005006007008009001,000
TypeIDPosition(s)Description
DNA binding938-985Integrase-type

GO annotations

AspectTerm
Molecular Functionaspartic-type endopeptidase activity
Molecular FunctionDNA binding
Molecular Functionexoribonuclease H activity
Molecular FunctionRNA stem-loop binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Molecular Functionzinc ion binding
Biological ProcessDNA integration
Biological ProcessDNA recombination
Biological Processestablishment of integrated proviral latency
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processviral genome integration into host DNA

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Pol protein

Gene names

    • Name
      pol

Organism names

Accessions

  • Primary accession
    A0A481S5Z9

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-44Disordered
Compositional bias11-32Polar residues
Domain76-145Peptidase A2
Domain199-389Reverse transcriptase
Domain589-712RNase H type-1
Domain718-759Integrase-type
Domain769-919Integrase catalytic
Domain938-985Integrase-type

Sequence similarities

Belongs to the retroviral Pol polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,003
  • Mass (Da)
    113,552
  • Last updated
    2019-06-05 v1
  • MD5 Checksum
    EA09F7C1B272450AF0F19105A86FD1F5
FFRENLAFQQREARKFSSEQNGTNSSTSRKLGGGGRDNLLPEAGTGGQGTLSSFNFPQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVRQYDQILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTNICTEMEKEGKILRIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRIKNPEIVIYQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAELELAENREILKEPVHGVYYDPTKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRSAHTNDVKQLTEVVQKVAIESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLETEPIVGAETFYVDGASNRETKLGKAGYVTDKGRQKVVTLTETTNQKTELHAVYLALQDSGSEVNIVTDSQYVLGIIHSQPDRSESELVNQIIEKLIEKDKVYLSWVPAHKGIGGNEQVDKLVSSGIRKVLFLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGSNFTSAAVKAACWWANITQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGNDCVAGRQDED

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias11-32Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK397970
EMBL· GenBank· DDBJ
QBG81398.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help