A0A480VC23 · A0A480VC23_PIG

  • Protein
    Phosphatidylethanolamine N-methyltransferase
  • Gene
    PEMT
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.

Catalytic activity

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site158-160S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site240-241S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial membrane
Molecular Functionphosphatidyl-N-dimethylethanolamine N-methyltransferase activity
Molecular Functionphosphatidyl-N-methylethanolamine N-methyltransferase activity
Molecular Functionphosphatidylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylethanolamine N-methyltransferase
  • EC number
  • Short names
    PEAMT
    ; PEMT
  • Alternative names
    • Phospholipid methyltransferase
      (PLMT
      )

Gene names

    • Name
      PEMT

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Duroc
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    A0A480VC23

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Note: Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria.

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-72Lumenal
Transmembrane73-92Helical
Intramembrane73-93Helical
Topological domain94-105Lumenal
Topological domain127-153Cytoplasmic
Transmembrane154-179Helical
Topological domain175-217Lumenal
Topological domain239-259Cytoplasmic

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-44Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    259
  • Mass (Da)
    27,981
  • Last updated
    2019-06-05 v1
  • Checksum
    A312ACFC6F352EA9
MGRHGGRFCGPGAPARPARQPLQGGPRPGAPASEDHAGPGGGARLLRGLRQPGPQADLCVMTRLLGYVDPSDARFVAAVLTIAFNPLFWNVVARWEHKTRKLSRAFGSPRLACYTLGGAILLLNLLRSHCFTQAMLSQPQMESLGGPTGYRLGLALLGVGSVFVLSSFLALGFTGTFLGDYFGILMEARVTRFPFSVLDNPMYWGSTAVYLGWALMHASPTGLLLTLVVAAIYKLAILFEEPFTAEIYRQRGSQARKRS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q7YRH5Q7YRH5_PIGPEMT199
A0A5G2QX89A0A5G2QX89_PIGPEMT267

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQIR01219262
EMBL· GenBank· DDBJ
HDB74739.1
EMBL· GenBank· DDBJ
Transcribed RNA
DQIR01226080
EMBL· GenBank· DDBJ
HDB81557.1
EMBL· GenBank· DDBJ
Transcribed RNA
DQIR01252154
EMBL· GenBank· DDBJ
HDC07632.1
EMBL· GenBank· DDBJ
Transcribed RNA
DQIR01256029
EMBL· GenBank· DDBJ
HDC11507.1
EMBL· GenBank· DDBJ
Transcribed RNA

Genome annotation databases

Similar Proteins

Disclaimer

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