A0A455WF70 · A0A455WF70_MARNT

Function

function

Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ cation per monomer.
Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

Note: Binds 1 nickel ion per monomer.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.

Features

Showing features for site, binding site.

TypeIDPosition(s)Description
Site95May play a role in metal incorporation in vivo
Binding site96Fe2+ (UniProtKB | ChEBI)
Binding site96Ni2+ (UniProtKB | ChEBI)
Binding site98Fe2+ (UniProtKB | ChEBI)
Binding site98Ni2+ (UniProtKB | ChEBI)
Site101May play a role in transmitting local conformational changes
Binding site102Fe2+ (UniProtKB | ChEBI)
Binding site102Ni2+ (UniProtKB | ChEBI)
Site104Important to generate the dianion
Binding site140Fe2+ (UniProtKB | ChEBI)
Binding site140Ni2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionacireductone dioxygenase (Ni2+-requiring) activity
Molecular Functionacireductone dioxygenase [iron(II)-requiring] activity
Molecular Functioniron ion binding
Molecular Functionnickel cation binding
Biological ProcessL-methionine salvage from methylthioadenosine
Biological ProcessL-methionine salvage from S-adenosylmethionine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acireductone dioxygenase
  • Alternative names
    • 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
      (DHK-MTPene dioxygenase
      )
    • Acireductone dioxygenase (Fe(2+)-requiring)
      (ARD'
      ; Fe-ARD
      ) (EC:1.13.11.54
      ) . EC:1.13.11.54 (UniProtKB | ENZYME | Rhea)
    • Acireductone dioxygenase (Ni(2+)-requiring)
      (ARD
      ; Ni-ARD
      ) (EC:1.13.11.53
      ) . EC:1.13.11.53 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      mtnD
    • ORF names
      YBY_23310

Organism names

Accessions

  • Primary accession
    A0A455WF70

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil47-74

Sequence similarities

Belongs to the acireductone dioxygenase (ARD) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    186
  • Mass (Da)
    21,160
  • Last updated
    2019-06-05 v1
  • Checksum
    A120D9A82C00F27B
MTTLSIFHQSQPDEAHTVMTDPGAIGDALARHGVRFEQWPTRDLPADASQEQILEAYSEEVERLKQECGFQTADVVSLNPDNPQKEAFRQKFLDEHTHSEDEVRFFVRGQGLFYLHFGDQVYALLCQKNDLISVPDGTRHWFDMGPEPQFTCIRLFTNPEGWVASFTGEDIASRLPRYERLAGVAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP019537
EMBL· GenBank· DDBJ
BBJ04482.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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