A0A455LI28 · A0A455LI28_EAV

Function

Catalytic activity

Features

Showing features for active site, site, binding site.

TypeIDPosition(s)Description
Active site164For Nsp1 papain-like cysteine proteinase activity
Active site230For Nsp1 papain-like cysteine proteinase activity
Site260-261Cleavage; by PCP
Active site270For Nsp2 cysteine proteinase activity
Binding site319Zn2+ 1 (UniProtKB | ChEBI)
Active site332For Nsp2 cysteine proteinase activity
Binding site349Zn2+ 1 (UniProtKB | ChEBI)
Binding site354Zn2+ 1 (UniProtKB | ChEBI)
Binding site356Zn2+ 1 (UniProtKB | ChEBI)
Site831-832Cleavage; by Nsp2 cysteine proteinase
Site1064-1065Cleavage; by 3CLSP
Active site1103Charge relay system; for 3C-like serine proteinase activity
Active site1129Charge relay system; for 3C-like serine proteinase activity
Active site1184Charge relay system; for 3C-like serine proteinase activity
Site1268-1269Cleavage; by 3CLSP; in major pathway
Site1430-1431Cleavage; by 3CLSP; in minor pathway
Site1452-1453Cleavage; by 3CLSP; in minor pathway
Site1575-1576Cleavage; by 3CLSP
Site1677-1678Cleavage; by 3CLSP
Site2370-2371Cleavage; by 3CLSP
Binding site2374Zn2+ 2 (UniProtKB | ChEBI)
Binding site2377Zn2+ 2 (UniProtKB | ChEBI)
Binding site2387Zn2+ 3 (UniProtKB | ChEBI)
Binding site2392Zn2+ 2 (UniProtKB | ChEBI)
Binding site2395Zn2+ 2 (UniProtKB | ChEBI)
Binding site2399Zn2+ 3 (UniProtKB | ChEBI)
Binding site2402Zn2+ 3 (UniProtKB | ChEBI)
Binding site2403Zn2+ 3 (UniProtKB | ChEBI)
Binding site2412Zn2+ 4 (UniProtKB | ChEBI)
Binding site2414Zn2+ 4 (UniProtKB | ChEBI)
Binding site2423Zn2+ 4 (UniProtKB | ChEBI)
Binding site2426Zn2+ 4 (UniProtKB | ChEBI)
Site2429Involved in mRNA transcription process
Site2837-2838Cleavage; by 3CLSP
Active site2963
Active site2978
Active site3007
Site3056-3057Cleavage; by 3CLSP

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionendonuclease activity
Molecular Functionhydrolase activity, acting on acid anhydrides
Molecular Functionlyase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA nuclease activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionserine-type exopeptidase activity
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral protein processing
Biological Processviral RNA genome replication
Biological Processviral translational frameshifting

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Replicase polyprotein 1ab
  • Alternative names
    • ORF1ab polyprotein

Gene names

    • Name
      ORF1ab

Organism names

  • Taxonomic identifier
  • Strain
    • KY84-L136A-S726
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Arnidovirineae > Arteriviridae > Equarterivirinae > Alphaarterivirus > Alphaarterivirus equid
  • Virus hosts

Accessions

  • Primary accession
    A0A455LI28

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane603-621Helical
Transmembrane627-646Helical
Transmembrane832-853Helical
Transmembrane903-923Helical
Transmembrane935-958Helical
Transmembrane970-995Helical
Transmembrane1318-1343Helical
Transmembrane1386-1409Helical

Keywords

PTM/Processing

Features

Showing features for glycosylation.

TypeIDPosition(s)Description
Glycosylation1501N-linked (GlcNAc...) asparagine; by host

PTM databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain66-156Peptidase C31
Domain157-260Peptidase C32
Domain261-360Peptidase C33
Region388-454Disordered
Compositional bias433-447Pro residues
Domain1065-1268Peptidase S32
Region1577-1614Disordered
Compositional bias1593-1614Basic and acidic residues
Domain1716-1883NiRAN
Domain2116-2251RdRp catalytic
Domain2371-2438AV ZBD
Domain2496-2793+RNA virus helicase C-terminal
Domain2840-2930AV-Nsp11N/CoV-Nsp15M
Domain2932-3054NendoU

Sequence similarities

Belongs to the arteriviridae polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,175
  • Mass (Da)
    345,503
  • Last updated
    2019-06-05 v1
  • Checksum
    3FC89DDAF7C3E653
MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECLRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYRAAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTIDQEQDGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKSYYVCDISEADWSCLPAGNYGGYNPPGDGACGYRCLAFMNGATAVSAGCSSDLWCDDELAYRVFQLSPTFTVTIPGGRVCPNAKHVMICDKQHWRVKRAKGVGLCLDESCFRGTCNCQRMSGPPPAPVSAAVLDHILEAATFGNVRVVTTEEQSRPVPAPRARPSVNSSGDGKDPAPVPPVPKPRTKLVKPNPTQAPIPAPRTRPPGTSAQEPPVNAETASALASKWRVAKTVYNSAERCRAELVQRARSVGDVLFQALPLKTPAVQRYIMTLKMMRSRFSWHCDTWYPLVAIACLLPIWPSLALLLSFAIGLIPSVGNNVVLTALLVSSANYVASMDHQCEGAACLALLEEEHYYRAVRWRPITGALSLVLNLLGQVGYISRSTFDAAYVPCTVFDLCSFAILYLCRNRCWRCFGRCVRVGPATHVLGSTGQRVSKLALIDLCDHFSKPTIDVVGMATGWSGCYTGAAAMERQCASTVDPHSFDQKKAGAIVYLTPPVNSGSALQCLNVMWKRPIGSTVLGEQTGAVVTAVKSISFSPPCCVSTTLPTRPGVTVVDHALYNRLTASGVDPALLRVGQGDFLKLNPGFRLIGGWIYGLCYFVLVVVSTFTCLPIKCGIGTRDPFCRRVFSVPVTKTQEHCHAGMCASAEGISLDSLGLSQLQSYWIAAVTSGLVVLLVCHRLAISALDLLTLASPLVLLVFPWASVGLLLACSLAGAAVKIQLLATLFVNLFFPQAALVTMGYWACVAALAVYSLMGLRVKVNVPMCVTPAHFLLLARSAGQSREQMLRVSAAAPTNSLLGVARDCYVTGTTRLYIPKEGGMVFEGLFRSPKARGNVGFVAGSSYGTGSVWARDNEVVVLTASHVVGRANMATLKIGDTMLTLTFKKNGDFAEAVTTQSELPGHWPQLHFAQPTTGPASWCTATGDEEGLLSGEVCLAWTTSGDSGSAVVQGDAVVGIHTGSNTSGVAYVTTPSGKLLGADTVTLSSLSKHFTGPLTSIPKDIPDNIIADVDTVPRSLAMLIDGLSNRESSLSGPQLLLIACFMWSYLNQPAYLPYVLGFFAANFFLPKSVGRPVVTGLLWLCCLFTPLSMRLCLFHLVCATVTGNVVSLWFYIAAAGTSYLSEMWFGGYPTMLFVPRFLVYQFPGWAIGAVLAVCSVTMLAAALGYTLLLDVFSASGRFDRTFMMKYFLEGGVKESVTTSVTRAYGKPITQESLTAALAALTDDDFQFLSDVLDCRAVRSAMNLRAALTSFQVAQYRNILNASLQIDRDAARSRRLMAKLADFAVEQEVTAGDRVVVIDGLDRMAHFKDDLVLVPLTTKVVGGSRCTICDVVKEEANDTPVKPVPSRRRRKALPKGAQLEWDRHQEEKRNAGDDDFAVSNDYVKRVPKYWDPSDTRGTTVKIAGTTYQKVVDYSGNVHYVEHQEDLVDYVLGKGSYEGLDQDKVLDLTNMLKVDPTELSSKDKAKARQLAHLLLDLADPVEAVNQLNLRAPHIFPGDVGRRTFADSKDKGFVALHSRTMFLAARDFLFNIKFVCDEEFTKTPKDTLLGYVRACPGYWFIFRRTHRSLIDAYWDSMECVYALPTISDFDVSPGDVAVTGERWDFESPGGGRSKRLTADLVHAFQGYHGASYSYDDKVAVAVSGDPYRSDGVLYNTRWGNIPYSVPTNALEATACYRAGCEAVTDGTNVVATIGPFPEQQPIPDIPKSVLDNCADISCDAFIAPAAEAALCSDLEKYNLSTQGFVLPSVFSMVRAYLKEEIGDAPPLYLPSTVPSKNSQAGINGAEFPTKSLQSYCLIDDMVSRSMNSNLQTATMATCKRQYCSKYKIRSILGTNNYIGLGLRACLSGVTAAFQKAGKDGSPIYLGKSKFDPIPAPDKYCLETDLESCDRSTPALVRWFATNLIFELAGQPELVHSYVLNCCHDLVVAGSVAFTKRGGLSSGDPITSISNTIYSLVLYTQHMLLCGLEGYFPEIAEKYLDGSLELRDMFKYVRVYIYSDDVVLTTPNQHYAASFDRWVPHLQALLGFKVDPKKTVNTSSPSFLGCRFKQVDGKCYLASLQDRVTRSLLYHVGAKNPSEYYEAAVSIFKDSIICCDEDWWTDLHHRISSAARTDGVEFPTVEMLTSFRTKQYESAVCTVCGAAPVAKSACGGWFCGNCVPYHVGHCHTTSLFANCGHDIMYRSTYCTMCEGSPKQMVPKVPHPILDHLLCHIDYGSKEELTLIVADGRTTSPPGRYKVGHKVVAVVADVGGNIVFGCGPGSHLAVPLQDTLKGVVVNKALKNAAASEYVEGPPGSGKTFHLVKDVLAVVGSATLVVPTHASMLDCINKLKQEGADPYFVVPKYTVLDFPRPGCGNITVRLPQVGTSEGETFVDEVAYFSPVDLARILTQGRVKGYGDLNQLGCVGPASVPRDLWLRHFVSLEPLRACHRFGAAVCDLIKGIYPYYEPAPHTTKVVFVPNPDFEKGVVITAYHKDRGLGHRTIDSIQGCTFPVVTLRLPTPQSLTRPRAVVAVTRASQELYIYDPFDQLSGLLKFTKEAEAQDLIHGPPIACHLGQEIDLWSNEGLEYYKEVNLLYTHVPIKDGVIHSYPNCGPACGWEKQSNKISCLPRVAQNLGYHYSPDLPGFCPIPKELAEHWPVVSNDRYPNCLQITLQQVCELSKPCSAGYMVGQSVFVQTPGVTSYWLTEWVDGKARALPDSLFSSGRFETNSRAFLDDAEEKFAAAHPHACLGEITKSTVGGSHFIFSQYLPPLLPADAVALVGASLAGKAAKAACSVVDVYAPSFEPYLHPETLSRVYKIMIDFKPCRLMVWRNATFYVQEGVDAVTSALAAVSKLIKVPANEPVSFHVASGYRTNALVAPQAKISIGAYAAEWALSTEPPPAGYAIVRRYVVKRLLSSTEVFLCRRGVVSSTSVQTICALEGCKPLFNFLQIGSVIGPV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias433-447Pro residues
Compositional bias1593-1614Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG137442
EMBL· GenBank· DDBJ
AYF58842.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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