A0A455LHI1 · A0A455LHI1_GOBRA
- ProteinMethylcytosine dioxygenase TET
- Genetet3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1906 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Catalytic activity
- 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H+ + succinate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Note: The zinc ions have a structural role.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | nucleus | |
Molecular Function | 5-methylcytosine dioxygenase activity | |
Molecular Function | zinc ion binding | |
Biological Process | 5-methylcytosine catabolic process | |
Biological Process | chromosomal 5-methylcytosine DNA demethylation pathway | |
Biological Process | regulation of gene expression |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylcytosine dioxygenase TET
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Gobionidae > Sarcocheilichthyinae > Gobiocypris
Accessions
- Primary accessionA0A455LHI1
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 58-89 | Disordered | ||||
Sequence: TPGWVPEQAGKSSNPESQQGAWNGQSASTPVN | ||||||
Compositional bias | 62-89 | Polar residues | ||||
Sequence: VPEQAGKSSNPESQQGAWNGQSASTPVN | ||||||
Region | 208-230 | Disordered | ||||
Sequence: GASPKPHAQHRYSQSQPQQCGGN | ||||||
Compositional bias | 215-230 | Polar residues | ||||
Sequence: AQHRYSQSQPQQCGGN | ||||||
Region | 294-413 | Disordered | ||||
Sequence: TVVPPGESSPANNHQHLPTSYPQSMPQVVSSSSGPLFSSSAIPQSIPPGHYPQEVSSWEQQRPQSQGEASAPNSSHYASPYPSSKSPFTSIQPCTPNPRPQQWNQGTAGSCERSSPRNPW | ||||||
Region | 562-602 | Disordered | ||||
Sequence: SPVTIKQEHKEPKKKKSAQSSPLLKQPVGGLFGPLGTPLPK | ||||||
Compositional bias | 565-579 | Basic and acidic residues | ||||
Sequence: TIKQEHKEPKKKKSA | ||||||
Region | 649-669 | Disordered | ||||
Sequence: LPGMEAGLPPSQVAESHPAPA | ||||||
Compositional bias | 757-795 | Polar residues | ||||
Sequence: GDTISSSSAAETPENGPAQPVVTESQLNSGQTRPESLSP | ||||||
Region | 757-834 | Disordered | ||||
Sequence: GDTISSSSAAETPENGPAQPVVTESQLNSGQTRPESLSPKQPVNCPPVPTNESEPMDEGQKDMTESLKEKTPLPSEEL | ||||||
Compositional bias | 811-834 | Basic and acidic residues | ||||
Sequence: PMDEGQKDMTESLKEKTPLPSEEL | ||||||
Domain | 1108-1806 | Methylcytosine dioxygenase TET1-3 oxygenase | ||||
Sequence: SWSMYFNGCKYARSKQPRKFGLQGDHPKEEDDLRDNFQNLATHVAPLYKRLAPQAYSNQCANEDVASDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLHNGCTVVCTLTKEDNRRVGTIPEDEQLHVLPLYKISTTDEFGSEENQRLKMQTGAIHVLSNFRREVRKLPEPAKSCRQRRLEAKKAASEKKNRKLQLAETPEKTIKMEMHHVESPQPQQGNKAIPKQEVKPTIKKEPVDRFQPFNGAIHGYPALRNGKTTPDPHSMSSSFSYPGNYARGHIPTNSQPPAQSPINGFHPNLQDIRYRYYNYPPSALFPPELLGYDNGAWPKAGDPSSTPFDQKPDVQCLQAKLAQAYPSRLGQSQQQMADVSRQGYTHPSEVSQSPVPPSRTPSVSLEQTHRSTPIIKQEPMDVPLYDGRLDGQAQSCPSTPSTTPNPEGWPEHKSNGSIVSKGWDGNIRAGPTNLAFTPDKQRLHQQHPHQHEHPQYPQQQQWNSYPCPNTLMTSPAPSPSPSLKGGSSPAPSPHPSTPRQWGSPAPSPQPKAWGPYGPMGYRTGGIRQGNPVGAFPDKMLSQAGENCGSAPLGLQEKAWKSGGGSAAGSTPSPAPEGRLFPDALQRSNGQACRDSEAETQSERDPEDDEVWSDSEHNFLDPNIGGVAVAPAHGSILIECARRELHATTPLKRPDRSHPSRISLVFYQHK | ||||||
Region | 1279-1301 | Disordered | ||||
Sequence: AKSCRQRRLEAKKAASEKKNRKL | ||||||
Region | 1383-1403 | Disordered | ||||
Sequence: ARGHIPTNSQPPAQSPINGFH | ||||||
Compositional bias | 1464-1511 | Polar residues | ||||
Sequence: SRLGQSQQQMADVSRQGYTHPSEVSQSPVPPSRTPSVSLEQTHRSTPI | ||||||
Region | 1464-1750 | Disordered | ||||
Sequence: SRLGQSQQQMADVSRQGYTHPSEVSQSPVPPSRTPSVSLEQTHRSTPIIKQEPMDVPLYDGRLDGQAQSCPSTPSTTPNPEGWPEHKSNGSIVSKGWDGNIRAGPTNLAFTPDKQRLHQQHPHQHEHPQYPQQQQWNSYPCPNTLMTSPAPSPSPSLKGGSSPAPSPHPSTPRQWGSPAPSPQPKAWGPYGPMGYRTGGIRQGNPVGAFPDKMLSQAGENCGSAPLGLQEKAWKSGGGSAAGSTPSPAPEGRLFPDALQRSNGQACRDSEAETQSERDPEDDEVWSD | ||||||
Compositional bias | 1529-1547 | Polar residues | ||||
Sequence: QAQSCPSTPSTTPNPEGWP | ||||||
Compositional bias | 1589-1618 | Polar residues | ||||
Sequence: EHPQYPQQQQWNSYPCPNTLMTSPAPSPSP | ||||||
Compositional bias | 1619-1650 | Pro residues | ||||
Sequence: SLKGGSSPAPSPHPSTPRQWGSPAPSPQPKAW | ||||||
Region | 1853-1873 | Disordered | ||||
Sequence: RKWAAGSASPSPGQTKDKREG |
Sequence similarities
Belongs to the TET family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,906
- Mass (Da)208,242
- Last updated2019-06-05 v1
- ChecksumCB0C8FFF27B75AA8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 62-89 | Polar residues | ||||
Sequence: VPEQAGKSSNPESQQGAWNGQSASTPVN | ||||||
Compositional bias | 215-230 | Polar residues | ||||
Sequence: AQHRYSQSQPQQCGGN | ||||||
Compositional bias | 565-579 | Basic and acidic residues | ||||
Sequence: TIKQEHKEPKKKKSA | ||||||
Compositional bias | 757-795 | Polar residues | ||||
Sequence: GDTISSSSAAETPENGPAQPVVTESQLNSGQTRPESLSP | ||||||
Compositional bias | 811-834 | Basic and acidic residues | ||||
Sequence: PMDEGQKDMTESLKEKTPLPSEEL | ||||||
Compositional bias | 1464-1511 | Polar residues | ||||
Sequence: SRLGQSQQQMADVSRQGYTHPSEVSQSPVPPSRTPSVSLEQTHRSTPI | ||||||
Compositional bias | 1529-1547 | Polar residues | ||||
Sequence: QAQSCPSTPSTTPNPEGWP | ||||||
Compositional bias | 1589-1618 | Polar residues | ||||
Sequence: EHPQYPQQQQWNSYPCPNTLMTSPAPSPSP | ||||||
Compositional bias | 1619-1650 | Pro residues | ||||
Sequence: SLKGGSSPAPSPHPSTPRQWGSPAPSPQPKAW |