A0A455LHI1 · A0A455LHI1_GOBRA

Function

function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: The zinc ions have a structural role.

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentnucleus
Molecular Function5-methylcytosine dioxygenase activity
Molecular Functionzinc ion binding
Biological Process5-methylcytosine catabolic process
Biological Processchromosomal 5-methylcytosine DNA demethylation pathway
Biological Processregulation of gene expression

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylcytosine dioxygenase TET
  • EC number

Gene names

    • Name
      tet3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Gobionidae > Sarcocheilichthyinae > Gobiocypris

Accessions

  • Primary accession
    A0A455LHI1

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region58-89Disordered
Compositional bias62-89Polar residues
Region208-230Disordered
Compositional bias215-230Polar residues
Region294-413Disordered
Region562-602Disordered
Compositional bias565-579Basic and acidic residues
Region649-669Disordered
Compositional bias757-795Polar residues
Region757-834Disordered
Compositional bias811-834Basic and acidic residues
Domain1108-1806Methylcytosine dioxygenase TET1-3 oxygenase
Region1279-1301Disordered
Region1383-1403Disordered
Compositional bias1464-1511Polar residues
Region1464-1750Disordered
Compositional bias1529-1547Polar residues
Compositional bias1589-1618Polar residues
Compositional bias1619-1650Pro residues
Region1853-1873Disordered

Sequence similarities

Belongs to the TET family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,906
  • Mass (Da)
    208,242
  • Last updated
    2019-06-05 v1
  • Checksum
    CB0C8FFF27B75AA8
MEIGSHDRLEQGVLNHELSNGLSKHANEENICDEEVRGVAREKHQHDYHEGARCISQTPGWVPEQAGKSSNPESQQGAWNGQSASTPVNDVDMEDARTLVAFSATVGSLPPYTNHQTSQTPTAQLYERFHQEMSNGGVEARKKGVDGELCPPEDLNTLQAALSKARHGHKPPNCDCDGPDCPDYLEWLEKQIKMVANSQDKGSCKIVGASPKPHAQHRYSQSQPQQCGGNLLCMQDTNSQPLVSQPSAPRPFGPPAPIPCSPSVLSIAKERNVSLQTAIAIEALTQLSATVPQTVVPPGESSPANNHQHLPTSYPQSMPQVVSSSSGPLFSSSAIPQSIPPGHYPQEVSSWEQQRPQSQGEASAPNSSHYASPYPSSKSPFTSIQPCTPNPRPQQWNQGTAGSCERSSPRNPWMMENTESQLRFVNPSQGSSDPVSELKQLLGDTGGKYTNSAFKFPLLHPSLQDGRKGSLAGVPHIKQEVDTKEYLGSGCAVMGQDGMLNGQQPFQGQQFSSTIRHSTQAALQQHLHHKRNLFSNSPAFSPLAPMACQNLRKWWPQSISESPVTIKQEHKEPKKKKSAQSSPLLKQPVGGLFGPLGTPLPKPKQIVIKKHKQKASQPTFLPQKQITISTPPFISSRYAPSLSQLVPSLPGMEAGLPPSQVAESHPAPAQSQEIIFNSSSASISENTHSSSSPLSVLAPSTQKVIACSGPAGPNDSIPTTSITLQTSTTQPIPSLAGLSNLDPKFEELIRQFEEEFGDTISSSSAAETPENGPAQPVVTESQLNSGQTRPESLSPKQPVNCPPVPTNESEPMDEGQKDMTESLKEKTPLPSEELCTVKRESEECEVDMKSGQLLSIAQDAFLERQHPFATPFSPPNKRIKIESSGGVTVLSTTACFSADREGDDLNTPTKDFPSSPSLKGFLESPLRYLDTPTKSLLDTPGKNSQPDFPICDCVDQILEKDEGPYYNHLGSGPDVASVRKLMEERYGEKGEAVRIEKVVYTGREGKSSQGCPIAKWVIRRSSEKEKLLCVVKQRPGHHCANSVIVVVILAWEGVPRALGDKLYRELTETIIKYGNPTSRRCGLNDDRTCACQGKDQDTCGASFSFGCSWSMYFNGCKYARSKQPRKFGLQGDHPKEEDDLRDNFQNLATHVAPLYKRLAPQAYSNQCANEDVASDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLHNGCTVVCTLTKEDNRRVGTIPEDEQLHVLPLYKISTTDEFGSEENQRLKMQTGAIHVLSNFRREVRKLPEPAKSCRQRRLEAKKAASEKKNRKLQLAETPEKTIKMEMHHVESPQPQQGNKAIPKQEVKPTIKKEPVDRFQPFNGAIHGYPALRNGKTTPDPHSMSSSFSYPGNYARGHIPTNSQPPAQSPINGFHPNLQDIRYRYYNYPPSALFPPELLGYDNGAWPKAGDPSSTPFDQKPDVQCLQAKLAQAYPSRLGQSQQQMADVSRQGYTHPSEVSQSPVPPSRTPSVSLEQTHRSTPIIKQEPMDVPLYDGRLDGQAQSCPSTPSTTPNPEGWPEHKSNGSIVSKGWDGNIRAGPTNLAFTPDKQRLHQQHPHQHEHPQYPQQQQWNSYPCPNTLMTSPAPSPSPSLKGGSSPAPSPHPSTPRQWGSPAPSPQPKAWGPYGPMGYRTGGIRQGNPVGAFPDKMLSQAGENCGSAPLGLQEKAWKSGGGSAAGSTPSPAPEGRLFPDALQRSNGQACRDSEAETQSERDPEDDEVWSDSEHNFLDPNIGGVAVAPAHGSILIECARRELHATTPLKRPDRSHPSRISLVFYQHKNLNQPCHGLALWESKMKLLAERARQRQQEAALLGLSQEDIKAYGKKRKWAAGSASPSPGQTKDKREGVITRMAPTQHTTTTVTASPYPSTHLTGPYSRFV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias62-89Polar residues
Compositional bias215-230Polar residues
Compositional bias565-579Basic and acidic residues
Compositional bias757-795Polar residues
Compositional bias811-834Basic and acidic residues
Compositional bias1464-1511Polar residues
Compositional bias1529-1547Polar residues
Compositional bias1589-1618Polar residues
Compositional bias1619-1650Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG763217
EMBL· GenBank· DDBJ
AYE92138.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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