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A0A452SMX4 · A0A452SMX4_URSAM

Function

function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadherens junction
Cellular Componentapical junction complex
Cellular Componentcatenin complex
Cellular Componentcortical actin cytoskeleton
Cellular Componentcytoplasmic side of plasma membrane
Cellular Componentdesmosome
Cellular Componentendosome
Cellular Componentflotillin complex
Cellular Componentlamellipodium
Cellular Componentlateral plasma membrane
Cellular Componentperinuclear region of cytoplasm
Cellular Componenttrans-Golgi network
Molecular Functionankyrin binding
Molecular Functionbeta-catenin binding
Molecular Functioncadherin binding
Molecular Functioncalcium ion binding
Molecular Functiongamma-catenin binding
Molecular FunctionGTPase activating protein binding
Molecular Functionidentical protein binding
Biological Processadherens junction organization
Biological Processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processcell morphogenesis
Biological Processcell-cell adhesion mediated by cadherin
Biological Processcell-cell junction assembly
Biological Processcellular response to indole-3-methanol
Biological Processcellular response to lithium ion
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules
Biological Processnegative regulation of cell migration
Biological Processnegative regulation of cell-cell adhesion
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of protein import into nucleus
Biological Processprotein localization to plasma membrane
Biological Processsynapse assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cadherin-1
  • Alternative names
    • Epithelial cadherin

Gene names

    • Name
      CDH1

Organism names

Accessions

  • Primary accession
    A0A452SMX4

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane708-730Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_501940144823-881Cadherin-1

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain178-260Cadherin
Domain261-373Cadherin
Domain374-484Cadherin
Domain485-593Cadherin
Region746-766Disordered
Region786-807Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    881
  • Mass (Da)
    97,701
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    72F2255D477CFABFC01213B2832AFF81
MGPRYPSVSAFLLLLQVSSWLCQEPEPCRPGFGADRYTFTVPRRHLERGRALGRVSFEGCTGQPRTAYIADDTRFKVSTDGVVTVKRPLQLHKPEMSFLVHAWDSSRRKLSTRVTLKAAEHHHHHRHDTLSETQTEVLTFPNSQRGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNRDKEIKVFYSITGQGADTPPVGVFVIERETGWLKVTEPLDREQIAKYILYSHAVSSNGNAVEDPMEIVITVTDQNDNKPEFTQEVFEGSVMEGALPGTSVMQVTATDADDDVNTYNAAIAYRIVTQDPPLPSSMMFTINKDTGVISVLTTGLDRETIPTYTLVVEAADLQGEGLSTTATAVITVTDANDNPPVFKPTTYQGQVPENKADVEIAVLKVTDADVPNTPAWQAVYTILNNNNEQFVVTTDPVTNDGILKTAKGLDYEAKQQYVLYVTVVNVAPFEVILSTSTATVTVDVEDVNEAPVFKPCPKVVEIPEDFGVGQEITSYTAEDPDKYMEQRITYRIWRDAASWLEINPESGAIFTRAELDREDIEHVKNSTYEAIIVAIDNGSPVATGTGTLLLILSDVNDNGPVPEPRSMDFCQKNPQPRVININDPDLPPNTSPFTAELTHGASVNWTIEYNDQAHESLILKPKKTLELGDYKINLKLTDNQNKDQVTTLDVFVCDCEGVVNSCKRTAPYAEAGLQVPAILGILGGILALLILILLLLLFVRRRGVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLLSVPQYRPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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