A0A452SDY7 · A0A452SDY7_URSAM

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchylomicron remnant
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular exosome
Cellular Componentextracellular matrix
Cellular Componentglutamatergic synapse
Cellular ComponentGolgi apparatus
Cellular Componenthigh-density lipoprotein particle
Cellular Componentintermediate-density lipoprotein particle
Cellular Componentlow-density lipoprotein particle
Cellular Componentmelanosome
Cellular Componentmultivesicular body, internal vesicle
Cellular Componentplasma membrane
Cellular Componentsynaptic cleft
Cellular Componentvery-low-density lipoprotein particle
Molecular Functionamyloid-beta binding
Molecular Functionantioxidant activity
Molecular Functioncholesterol transfer activity
Molecular Functionenzyme binding
Molecular Functionheparan sulfate proteoglycan binding
Molecular Functionheparin binding
Molecular Functionlipoprotein particle binding
Molecular Functionlow-density lipoprotein particle receptor binding
Molecular Functionmetal chelating activity
Molecular Functionpeptidyl-prolyl cis-trans isomerase activity
Molecular Functionphosphatidylcholine-sterol O-acyltransferase activator activity
Molecular Functionphospholipid binding
Molecular Functionprotein homodimerization activity
Molecular Functionreceptor ligand activity
Molecular Functiontau protein binding
Molecular Functionvery-low-density lipoprotein particle receptor binding
Biological ProcessAMPA glutamate receptor clustering
Biological Processamyloid precursor protein metabolic process
Biological Processartery morphogenesis
Biological Processcellular response to lipoprotein particle stimulus
Biological Processcholesterol catabolic process
Biological Processcholesterol efflux
Biological Processcholesterol homeostasis
Biological Processchylomicron remnant clearance
Biological Processfatty acid homeostasis
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processgene expression
Biological Processhigh-density lipoprotein particle assembly
Biological Processhigh-density lipoprotein particle clearance
Biological Processhigh-density lipoprotein particle remodeling
Biological Processintermediate-density lipoprotein particle clearance
Biological Processintracellular calcium ion homeostasis
Biological Processlipid transport involved in lipid storage
Biological Processlipoprotein biosynthetic process
Biological Processlipoprotein catabolic process
Biological Processlocomotory exploration behavior
Biological Processlong-chain fatty acid transport
Biological Processlong-term memory
Biological Processlow-density lipoprotein particle remodeling
Biological Processmaintenance of location in cell
Biological Processmelanosome organization
Biological Processnegative regulation of amyloid fibril formation
Biological Processnegative regulation of amyloid-beta formation
Biological Processnegative regulation of blood vessel endothelial cell migration
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of cholesterol biosynthetic process
Biological Processnegative regulation of endothelial cell proliferation
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of long-term synaptic potentiation
Biological Processnegative regulation of MAP kinase activity
Biological Processnegative regulation of neuron apoptotic process
Biological Processnegative regulation of neuron projection development
Biological Processnegative regulation of platelet activation
Biological Processnegative regulation of protein secretion
Biological Processnegative regulation of smooth muscle cell proliferation
Biological Processnegative regulation of triglyceride metabolic process
Biological Processneuron projection development
Biological Processnitric oxide-cGMP-mediated signaling
Biological ProcessNMDA glutamate receptor clustering
Biological Processphospholipid efflux
Biological Processpositive regulation by host of viral process
Biological Processpositive regulation of amyloid-beta clearance
Biological Processpositive regulation of cholesterol efflux
Biological Processpositive regulation of cholesterol metabolic process
Biological Processpositive regulation of CoA-transferase activity
Biological Processpositive regulation of dendritic spine development
Biological Processpositive regulation of dendritic spine maintenance
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of endocytosis
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of lipid biosynthetic process
Biological Processpositive regulation of lipid transport across blood-brain barrier
Biological Processpositive regulation of low-density lipoprotein particle receptor catabolic process
Biological Processpositive regulation of membrane protein ectodomain proteolysis
Biological Processpositive regulation of neuron projection development
Biological Processpositive regulation of nitric oxide biosynthetic process
Biological Processpositive regulation of nitric-oxide synthase activity
Biological Processpositive regulation of phospholipid efflux
Biological Processprotein import
Biological Processreceptor-mediated endocytosis
Biological Processregulation of behavioral fear response
Biological Processregulation of Cdc42 protein signal transduction
Biological Processregulation of cellular response to very-low-density lipoprotein particle stimulus
Biological Processregulation of innate immune response
Biological Processregulation of proteasomal protein catabolic process
Biological Processregulation of protein-containing complex assembly
Biological Processresponse to caloric restriction
Biological Processresponse to dietary excess
Biological Processresponse to oxidative stress
Biological Processreverse cholesterol transport
Biological Processtriglyceride homeostasis
Biological Processtriglyceride metabolic process
Biological Processvasodilation
Biological Processvery-low-density lipoprotein particle clearance
Biological Processvery-low-density lipoprotein particle remodeling
Biological Processvirion assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Apolipoprotein E

Gene names

    • Name
      APOE

Organism names

Accessions

  • Primary accession
    A0A452SDY7

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_501908862319-323Apolipoprotein E

Interaction

Subunit

Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain, coiled coil.

TypeIDPosition(s)Description
Compositional bias22-40Basic and acidic residues
Region22-46Disordered
Domain230-323PpiC
Coiled coil246-284

Sequence similarities

Belongs to the apolipoprotein A1/A4/E family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    323
  • Mass (Da)
    37,236
  • Last updated
    2019-05-08 v1
  • Checksum
    E1822DA11A18CACF
MKVLWAALVVALLAGCWADVEPEPKPEAEPKLEGESKLEPEAGRQTGQPWELALARFWDYLRWVQTMSEQVQEDVLSNRVIQELTTLMEETLKEVKMYTEEVEEQLGPLTSEMQARVTKELQAAQARLRSDMEDVRSRLTQYRGELQAMLGQSSDELRARLTSHLRKLRKRLLRDAEDLQKRLAVYRAGVREGTERSMDTITQQLWPLVMHVRTRQVIARSEGALPLRERAEALGQHLRGQLEEVGSRARSQLEEVREQVEVMRAKLEEQAEQMRQQAEAFQARLRSWFEPLVEDMQRQWAELVEKVQAAVGTGPTTAPVETQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias22-40Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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