A0A452S7V2 · A0A452S7V2_URSAM
- ProteinSodium/hydrogen exchanger
- GeneSLC9A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids816 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Electroneutral Na+ /H+ antiporter that extrudes Na+ in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H+ ions for extracellular Na+ in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li+ and functions also as a Na+/Li+ antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs.
Catalytic activity
- Li+(out) + H+(in) = Li+(in) + H+(out)
- Na+(in) + H+(out) = Na+(out) + H+(in)
- Li+(in) + Na+(out) = Li+(out) + Na+(in)
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium/hydrogen exchanger
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452S7V2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Basolateral cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-33 | Helical | |||
Transmembrane | 106-126 | Helical | |||
Transmembrane | 133-150 | Helical | |||
Transmembrane | 156-178 | Helical | |||
Transmembrane | 190-217 | Helical | |||
Transmembrane | 229-248 | Helical | |||
Transmembrane | 255-277 | Helical | |||
Transmembrane | 289-313 | Helical | |||
Transmembrane | 389-408 | Helical | |||
Transmembrane | 414-438 | Helical | |||
Transmembrane | 450-469 | Helical | |||
Transmembrane | 481-504 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 40-80 | Disordered | |||
Domain | 111-504 | Cation/H+ exchanger | |||
Domain | 601-686 | Sodium/hydrogen exchanger regulatory region | |||
Coiled coil | 626-653 | ||||
Region | 745-816 | Disordered | |||
Compositional bias | 773-795 | Polar residues | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length816
- Mass (Da)90,824
- Last updated2019-05-08 v1
- Checksum81224C932FAA19AC
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A452S7P9 | A0A452S7P9_URSAM | SLC9A1 | 782 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 773-795 | Polar residues | |||
Keywords
- Technical term