A0A452S7V2 · A0A452S7V2_URSAM

Function

function

Electroneutral Na+ /H+ antiporter that extrudes Na+ in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H+ ions for extracellular Na+ in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li+ and functions also as a Na+/Li+ antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentcation-transporting ATPase complex
Cellular Componentcytoplasm
Cellular Componentlateral plasma membrane
Cellular Componentmembrane raft
Cellular Componentnucleoplasm
Molecular Functioncalcium-dependent protein binding
Molecular Functioncalmodulin binding
Molecular Functionidentical protein binding
Molecular Functionphospholipid binding
Molecular Functionpotassium:proton antiporter activity
Molecular Functionprotein phosphatase 2B binding
Molecular Functionsodium:proton antiporter activity
Biological Processcellular response to acidic pH
Biological Processcellular response to epinephrine stimulus
Biological Processintracellular sodium ion homeostasis
Biological Processpositive regulation of calcineurin-NFAT signaling cascade
Biological Processpositive regulation of calcium:sodium antiporter activity
Biological Processpositive regulation of cardiac muscle hypertrophy
Biological Processpositive regulation of the force of heart contraction
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of cardiac muscle contraction by calcium ion signaling
Biological Processregulation of intracellular pH
Biological Processregulation of the force of heart contraction by cardiac conduction
Biological Processresponse to muscle stretch
Biological Processsodium ion import across plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/hydrogen exchanger

Gene names

    • Name
      SLC9A1

Organism names

Accessions

  • Primary accession
    A0A452S7V2

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane106-126Helical
Transmembrane133-150Helical
Transmembrane156-178Helical
Transmembrane190-217Helical
Transmembrane229-248Helical
Transmembrane255-277Helical
Transmembrane289-313Helical
Transmembrane389-408Helical
Transmembrane414-438Helical
Transmembrane450-469Helical
Transmembrane481-504Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, coiled coil, compositional bias.

Type
IDPosition(s)Description
Region40-80Disordered
Domain111-504Cation/H+ exchanger
Domain601-686Sodium/hydrogen exchanger regulatory region
Coiled coil626-653
Region745-816Disordered
Compositional bias773-795Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    816
  • Mass (Da)
    90,824
  • Last updated
    2019-05-08 v1
  • Checksum
    81224C932FAA19AC
MRLLWSGICGRAPPRIFPSLLVVVALAGLLPVLRSHGLQPSPTASTIRGSEPPRERSIGDVTTAPPELAPESRPVNHSVTEHSMKTRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYDRIGIVDIVLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTAHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPAERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLNRDPARVAEEDEDDDGGIVMRTKEPSSPGTDDVFTPGPSDSPSSQRIQRCLSDPGPHPEPGEGEPFIPKGQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A452S7P9A0A452S7P9_URSAMSLC9A1782

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias773-795Polar residues

Keywords

Genome annotation databases

Similar Proteins

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