A0A452RZK0 · A0A452RZK0_URSAM
- ProteinExtracellular sulfatase
- GeneSULF2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids870 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Catalytic activity
- an aryl sulfate + H2O = a phenol + sulfate + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 52 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 53 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 88 | Nucleophile | |||
Binding site | 88 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | |||
Binding site | 317 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 318 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameExtracellular sulfatase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452RZK0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-24 | ||||
Chain | PRO_5018825311 | 25-870 | Extracellular sulfatase | ||
Modified residue | 88 | 3-oxoalanine (Cys) | |||
Post-translational modification
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 44-374 | Sulfatase N-terminal | |||
Domain | 528-664 | Extracellular sulfatase C-terminal | |||
Region | 548-591 | Disordered | |||
Compositional bias | 566-580 | Basic and acidic residues | |||
Coiled coil | 628-655 | ||||
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length870
- Mass (Da)100,236
- Last updated2019-05-08 v1
- Checksum34B420EA6D4D8D3D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 566-580 | Basic and acidic residues | |||
Keywords
- Technical term