A0A452RQF9 · A0A452RQF9_URSAM
- ProteinUromodulin
- GeneUMOD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids649 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameUromodulin
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452RQF9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Lipid-anchor, GPI-anchor
Basolateral cell membrane ; Lipid-anchor, GPI-anchor
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MGQLSSPTSVWMVLMVTSWVLRAAST | ||||||
Chain | PRO_5019214538 | 27-649 | Uromodulin | |||
Sequence: DTLEARSCSDCHSNATCMENGTATTCSCQVGFTGNGLVCVDLDECVIPGAHNCSEDSSCVNTPGSYLCTCSDGFRLTPGLGCTDVDECAEPGLSHCHALATCINSKGNYSCVCPVGYLGDGQHCECSPGSCGPGLDCVPEGDTLMCVDPCQEYHILDEYWRSTEYGAGYTCDLGLSGWYRFMGPGGVSLAETCVPVLHCNTAAPMWLNGIHPSSDEGIVNRTACAHWSGHCCLWEAPVQVKACAGGYYVYNLTAPPECYLAYCTDPSSVLGTCEECSTEEDCKSDDGTWRCQCKQDFSITDLSLLERKLECGVNDIKVSLSKCQLKSLGFEKVFMYLRDSQCSGFSERGDRDWLSVVTPARDGPCGTVMMVYSHAPFSYPPXETHATYSNTLYLADEIIIRDRNIKINFACSYPLDMKISLKTSLQPMVSVLNISVGGTGMFTVRMALFQTPAYTQPYQGSSVTLTTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPRTKDPTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEIYLCDTFTEKCKPTCSGTRFRSGGITDQTHVLNLGPITRKSKRATPSPTFLFLKVWLPLLLLATLTLMSQ |
Keywords
- PTM
Interaction
Subunit
Homodimer that then polymerizes into long filaments. The filaments can additionally assemble laterally to form a sheet. The filaments consist of a zigzag-shaped backbone with laterally protruding arms which interact with bacterial adhesin fimH. Two fimH molecules can bind to a single UMOD monomer.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 67-109 | EGF-like | ||||
Sequence: DLDECVIPGAHNCSEDSSCVNTPGSYLCTCSDGFRLTPGLGCT | ||||||
Domain | 110-151 | EGF-like | ||||
Sequence: DVDECAEPGLSHCHALATCINSKGNYSCVCPVGYLGDGQHCE | ||||||
Domain | 336-601 | ZP | ||||
Sequence: ECGVNDIKVSLSKCQLKSLGFEKVFMYLRDSQCSGFSERGDRDWLSVVTPARDGPCGTVMMVYSHAPFSYPPXETHATYSNTLYLADEIIIRDRNIKINFACSYPLDMKISLKTSLQPMVSVLNISVGGTGMFTVRMALFQTPAYTQPYQGSSVTLTTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPRTKDPTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEIYLCDTFTEKCKPTCSGTRFRS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length649
- Mass (Da)70,833
- Last updated2019-05-08 v1
- Checksum7A028D14B7708B0D
Keywords
- Technical term